TY - JOUR
TI - Early alterations of the innate and adaptive immune statuses in sepsis
according to the type of underlying infection
AU - Gogos, Charalambos
AU - Kotsaki, Antigone
AU - Pelekanou, Aimilia and
AU - Giannikopoulos, George
AU - Vaki, Ilia
AU - Maravitsa, Panagiota and
AU - Adamis, Stephanos
AU - Alexiou, Zoi
AU - Andrianopoulos, George and
AU - Antonopoulou, Anastasia
AU - Athanassia, Sofia
AU - Baziaka, Fotini and
AU - Charalambous, Aikaterini
AU - Christodoulou, Sofia
AU - Dimopoulou, Ioanna
AU - and Floros, Ioannis
AU - Giannitsioti, Efthymia
AU - Gkanas, Panagiotis
AU - and Ioakeimidou, Aikaterini
AU - Kanellakopoulou, Kyriaki
AU - Karabela,
AU - Niki
AU - Karagianni, Vassiliki
AU - Katsarolis, Ioannis
AU - Kontopithari,
AU - Georgia
AU - Kopterides, Petros
AU - Koutelidakis, Ioannis
AU - Koutoukas,
AU - Pantelis
AU - Kranidioti, Hariklia
AU - Lignos, Michalis
AU - Louis,
AU - Konstantinos
AU - Lymberopoulou, Korina
AU - Mainas, Efstratios and
AU - Marioli, Androniki
AU - Massouras, Charalambos
AU - Mavrou, Irini and
AU - Mpalla, Margarita
AU - Michalia, Martha
AU - Mylona, Heleni
AU - Mytas,
AU - Vassilios
AU - Papanikolaou, Ilias
AU - Papanikolaou, Konstantinos and
AU - Patrani, Maria
AU - Perdios, Ioannis
AU - Plachouras, Diamantis and
AU - Pistiki, Aikaterini
AU - Protopapas, Konstantinos
AU - Rigaki, Kalliopi
AU - and Sakka, Vissaria
AU - Sartzi, Monika
AU - Skouras, Vassilios
AU - Souli,
AU - Maria
AU - Spyridaki, Aikaterini
AU - Strouvalis, Ioannis
AU - Tsaganos,
AU - Thomas
AU - Zografos, George
AU - Mandragos, Konstantinos and
AU - Klouva-Molyvdas, Phylis
AU - Maggina, Nina
AU - Giamarellou, Helen and
AU - Armaganidis, Apostolos
AU - Giamarellos-Bourboulis, Evangelos J.
JO - Critical Care and Resuscitation
PY - 2010
VL - 14
TODO - 3
SP - null
PB - BioMed Central Ltd.
SN - null
TODO - 10.1186/cc9031
TODO - null
TODO - Introduction: Although major changes of the immune system have been
described in sepsis, it has never been studied whether these may differ
in relation to the type of underlying infection or not. This was studied
for the first time.
Methods: The statuses of the innate and adaptive immune systems were
prospectively compared in 505 patients. Whole blood was sampled within
less than 24 hours of advent of sepsis; white blood cells were stained
with monoclonal antibodies and analyzed though a flow cytometer.
Results: Expression of HLA-DR was significantly decreased among patients
with severe sepsis/shock due to acute pyelonephritis and intraabdominal
infections compared with sepsis. The rate of apoptosis of natural killer
(NK) cells differed significantly among patients with severe
sepsis/shock due to ventilator-associated pneumonia (VAP) and
hospital-acquired pneumonia (HAP) compared with sepsis. The rate of
apoptosis of NKT cells differed significantly among patients with severe
sepsis/shock due to acute pyelonephritis, primary bacteremia and VAP/HAP
compared with sepsis. Regarding adaptive immunity, absolute counts of
CD4-lymphocytes were significantly decreased among patients with severe
sepsis/shock due to community-acquired pneumonia (CAP) and
intraabdominal infections compared with sepsis. Absolute counts of
B-lymphocytes were significantly decreased among patients with severe
sepsis/shock due to CAP compared with sepsis.
Conclusions: Major differences of the early statuses of the innate and
adaptive immune systems exist between sepsis and severe sepsis/shock in
relation to the underlying type of infection. These results may have a
major impact on therapeutics.
ER -