TY - JOUR TI - IRON OVERLOAD, CARDIAC AND OTHER FACTORS AFFECTING PREGNANCY IN THALASSEMIA MAJOR AU - Tsironi, Maria AU - Karagiorga, Markissia AU - Aessopos, Athanasios JO - Hemoglobin: Interrnational Journal for Hemoglobin Research PY - 2010 VL - 34 TODO - 3 SP - 240-250 PB - TAYLOR & FRANCIS LTD LONDON SN - 0363-0269 TODO - 10.3109/03630269.2010.485004 TODO - Thalassemia; Pregnancy; Iron; Oxidative stress; Chelation TODO - The reproductive thalassemic population is growing older and doctors confront the challenge of the thalassemic pregnancy. Pregnancy is characterized by dynamic multiple system changes, resulting in increased basal oxygen consumption, changes in energy substrate use by different organs and increased susceptibility to oxidative stress, while homozygous transfusion-dependent beta-thalassemia (beta-thal) patients manifest cardiac, hepatic, endocrine, and metabolic disorders attributable to chronic anoxia and iron overload. Pregnant thalassemic patients require significantly larger amount of total blood transfusion during pregnancy and iron overload increases the oxidative stress of pregnancy, while the risk for cardiovascular events, in a high cardiac output state, is augmented and chelation treatment is generally avoided due to the potential teratogenicity. Pregnancy in thalassemia major should be considered high risk, and be cared for by an expert team with special caution and sensitivity. ER -