TY - JOUR
TI - Increased left ventricular arrhythmogenicity in metabolic syndrome and
relationship with myocardial performance, risk factors for
atherosclerosis, and low-grade inflammation
AU - Voulgari, Christina
AU - Tentolouris, Nicholas
AU - Papadogiannis,
AU - Dimitrios
AU - Moyssakis, Ioannis
AU - Perrea, Despoina
AU - Kyriaki,
AU - Despoina
AU - Katsilambros, Nicholas
JO - Metabolism: Clinical and Experimental
PY - 2010
VL - 59
TODO - 2
SP - 159-165
PB - W B SAUNDERS CO-ELSEVIER INC
SN - 0026-0495
TODO - 10.1016/j.metabol.2009.06.028
TODO - null
TODO - Metabolic syndrome (MetS) is a clustering of cardiovascular risk factors
recently associated with left ventricular dysfunction Limited data exist
on the association between MetS and ventricular arrhythmogenicity This
study examined differences in ventricular arrhythmogenicity assessed by
classic (QT interval) and newer (spatial QRS-T angle [spQRS-Ta])
electrocardiographic markers in subjects with and without MetS A total
of 306 subjects, 153 with and 153 without MetS, matched for sex and age
were examined The spQRS-Ta, which vectorcardiographically quantifies the
deviation between the directions of ventricular depolarization and
repolarization, was measured using a computer-based electrocardiograph
Left ventricular mass index and myocardial performance were evaluated
echocardiographically The spQRS-Ta was significantly higher in subjects
with in comparison with those without MetS Left ventricular mass index,
QT interval. and its dispersion wet e not different between the 2 groups
Left ventricular myocardial performance was worse in subjects with MetS
and was associated with higher values of the spQRS-Ta Multivariate
linear regression analysis demonstrated MetS status as the strongest
predictor of ventricular arrhythmogenicity Addition of the
high-sensitivity C-reactive protein in the model increased the explained
variance of the spQRS-Ta by 11% In conclusion, ventricular
arrhythmogenicity is present in MetS and is associated with myocardial
dysfunction, risk factors for atherosclerosis, and low-grade
inflammation. The Independent association between the spQRS-Ta and MetS
implies that the clustering of the metabolic disturbances has additional
prognostic information than its individual components in terms of
ventricular arrhythmogenicity and may explain in part the excess
cardiovascular risk in subjects with MetS (C) 2010 Elsevier Inc All
rights reserved
ER -