TY - JOUR
TI - Increase in coronary blood flow by intra-aortic balloon counterpulsation
in a porcine model of myocardial reperfusion
AU - Bonios, Michael J.
AU - Pierrakos, Charalampos N.
AU - Argiriou, Michael
AU - and Dalianis, Argirios
AU - Terrovitis, John V.
AU - Dolou, Paraskevi and
AU - Drakos, Stavros G.
AU - Koudoumas, Dimitrios
AU - Charitos, Christos E.
AU - and Anastasiou-Nana, Maria I.
JO - International Journal of Cardiology
PY - 2010
VL - 138
TODO - 3
SP - 253-260
PB - Elsevier Ireland Ltd
SN - 0167-5273
TODO - 10.1016/j.ijcard.2008.08.015
TODO - Myocardial infarction; Intra-aortic balloon pump; Coronary blood flow;
Myocardial reperfusion
TODO - Background: Studies of the IABP have reported variable effects on
coronary blood flow (CBF). The purpose of the present study was to
measure the changes in coronary blood flow induced by intra-aortic
balloon pump (IABP) counterpulsation in normal and reperfused porcine
myocardium.
Methods: A 30-ml IABP was placed in the descending aorta of 6 open-chest
pigs. Each pig underwent occlusion of the mid-left anterior descending
(LAD) coronary artery for 1 h, followed by reperfusion for 2 h. The
effects of IABP support on systolic aortic pressure (SAP) and aortic
end-diastolic pressure were recorded. The mean CBF, distal to the LAD
occlusion site was measured at baseline and during reperfusion, with and
without IABP counterpulsation.
Results: The IABP decreased SAP and aortic end-diastolic pressure in
normal and reperfused myocardium, and maintained a peak aortic diastolic
augmentation at the level of SAP. In normal myocardium, the IABP
decreased mean CBF by 8.4+/-2.2% (p<0.001). At 2, 15, 30, 60, 90 and
120 min of reperfusion, the IABP increased mean CBF by 11.5+/-6.8%,
8.0+/-7.0%, 11.2+/-6.9%, 12.4+/-12.9%, 23.5+/-9.9% and 8.9+/-6.9%,
of the corresponding value without the assistance of the IABP (all
p<0.05).
Conclusions: In the normal heart, IABP counterpulsation decreased CBF,
probably because of a decrease in myocardial oxygen demand from a
decreased afterload. During reperfusion the IABP increased CBF,
suggesting that it might effectively mitigate the no-reflow phenomenon.
(C) 2008 Elsevier Ireland Ltd. All rights reserved.
ER -