TY - JOUR
TI - Beta-adrenergic receptor blockade and prostate peptide growth factor
expression in the rat
AU - Mitropoulos, Dionisios
AU - Kyroudi-Voulgari, Aspasia
AU - Stratigea,
AU - Filia
AU - Perea, Despina
AU - Boudoulas, Harisios
AU - Karayannacos,
AU - Panayotis
JO - Immunopharmacology and Immunotoxicology
PY - 2010
VL - 32
TODO - 1
SP - 105-109
PB - TAYLOR & FRANCIS LTD LONDON
SN - 0892-3973, 1532-2513
TODO - 10.3109/08923970903164326
TODO - beta-adrenoreceptor antagonists; peptide growth factors; rat; prostate;
propranolol
TODO - Results: At sacrifice, body weight as well as ventral prostate weight
and prostate morphology were not significantly affected by propranolol
treatment. Stromal elements and the majority of prostatic epithelial
cells in control animals demonstrated positive staining for the
anti-bFGF antibody, while positive staining for TGF beta was seen only
in epithelial cells. Propranolol treatment resulted in considerable
decrease of bFGF staining intensity in both stromal and epithelial
cells, while the immunostaining pattern for TGF beta was almost
abolished.
Results and Conclusions: The results from this study provide evidence to
suggest that prolonged propranolol treatment affects peptide growth
expression in the rat ventral prostate as in other tissues, and confirms
the notion that autonomic nervous system controls, at least partly,
prostate gland functional characteristics. Moreover, it may also affect
prostate homeostasis by intervening in stromal-epithelial interaction
through alterations in the expression of peptide growth factors without
affecting prostate volume.
ER -