TY - JOUR
TI - Circulating adipocyte fatty acid binding protein levels in healthy
preterm infants: Positive correlation with weight gain and
total-cholesterol levels
AU - Siahanidou, Tania
AU - Margeli, Alexandra
AU - Davradou, Maria and
AU - Apostolakou, Filia
AU - Papassotiriou, Ioannis
AU - Roma, Eleftheria and
AU - Mandyla, Helen
AU - Chrousos, George
JO - Early Human Development
PY - 2010
VL - 86
TODO - 4
SP - 197-201
PB - Elsevier Ireland Ltd
SN - 0378-3782
TODO - 10.1016/j.earlhumdev.2010.02.008
TODO - Fatty acid binding protein; Adipose tissue; Neonate; Insulin resistance
TODO - Background: Adipocyte fatty acid binding protein (a-FABP) has been
suggested to play an important role in the pathogenesis of metabolic
syndrome. Preterm infants are at risk for the later development of
insulin resistance, and, possibly, other components of metabolic
syndrome.
Aim: To determine circulating levels of a-FABP in preterm infants and
examine possible associations of a-FABP with metabolic indices (serum
lipids, glucose, and insulin levels, and homeostasis model assessment
index of insulin resistance [HOMA-IR]), levels of leptin and
adiponectin, anthropometric parameters and weight gain.
Study design: Prospective cohort study.
Subjects: 55 healthy preterm (mean [SD] gestational age 32.8 [1.8]
weeks) and 23 fullterm infants (reference group).
Outcome measures: Serum a-FABP, lipids, glucose, insulin, leptin and
adiponectin levels at 31.9 [10.4] days of life.
Results: Serum a-FABP levels did not differ significantly between
preterm and fullterm infants. A-FABP levels. correlated positively with
total-cholesterol [total-C] in both preterm and fullterm infants
(beta=0.33: p=0.01 and beta=0.33; p=0.04, respectively). In addition to
total-C, weight gain correlated independently with a-FABP levels in
preterm infants (beta=0.36, p = 0.01).
Conclusions: An association between a-FABP levels and indices of insulin
resistance was not present in infants studied. As the development of
insulin resistance in children born prematurely is possibly associated
with weight gain in early postnatal life, follow-up of our study
population is necessary to demonstrate whether a-FABP levels, shown to
correlate with weight gain in preterm infants, are a predictive marker
for the later development of insulin resistance in these infants. (C)
2010 Elsevier Ireland Ltd. All rights reserved.
ER -