TY - JOUR
TI - Anthropometric Measures, Body Mass Index, and Pancreatic Cancer A Pooled
Analysis From the Pancreatic Cancer Cohort Consortium (PanScan)
AU - Arslan, Alan A.
AU - Helzlsouer, Kathy J.
AU - Kooperberg, Charles and
AU - Shu, Xiao-Ou
AU - Steplowski, Emily
AU - Bueno-de-Mesquita, H. Bas and
AU - Fuchs, Charles S.
AU - Gross, Myron D.
AU - Jacobs, Eric J.
AU - LaCroix,
AU - Andrea Z.
AU - Petersen, Gloria M.
AU - Stolzenberg-Solomon, Rachael Z.
AU - and Zheng, Wei
AU - Albanes, Demetrius
AU - Amundadottir, Laufey and
AU - Bamlet, William R.
AU - Barricarte, Aurelio
AU - Bingham, Sheila A. and
AU - Boeing, Heiner
AU - Boutron-Ruault, Marie-Christine
AU - Buring, Julie E.
AU - and Chanock, Stephen J.
AU - Clipp, Sandra
AU - Gaziano, J. Michael and
AU - Giovannucci, Edward L.
AU - Hankinson, Susan E.
AU - Hartge, Patricia and
AU - Hoover, Robert N.
AU - Hunter, David J.
AU - Hutchinson, Amy
AU - Jacobs,
AU - Kevin B.
AU - Kraft, Peter
AU - Lynch, Shannon M.
AU - Manjer, Jonas and
AU - Manson, JoAnn E.
AU - McTiernan, Anne
AU - McWilliams, Robert R. and
AU - Mendelsohn, Julie B.
AU - Michaud, Dominique S.
AU - Palli, Domenico and
AU - Rohan, Thomas E.
AU - Slimani, Nadia
AU - Thomas, Gilles
AU - Tjonneland,
AU - Anne
AU - Tobias, Geoffrey S.
AU - Trichopoulos, Ditnitrios
AU - Virtamo,
AU - Jarmo
AU - Wolpin, Brian M.
AU - Yu, Kai
AU - Zeleniuch-Jacquotte, Anne and
AU - Patel, Alpa V.
JO - Polish Archives of Internal Medicine
PY - 2010
VL - 170
TODO - 9
SP - 791-802
PB - AMER MEDICAL ASSOC
SN - null
TODO - 10.1001/archinternmed.2010.63
TODO - null
TODO - Background: Obesity has been proposed as a risk factor for pancreatic
cancer.
Methods: Pooled data were analyzed from the National Cancer Institute
Pancreatic Cancer Cohort Consortium (PanScan) to study the association,
between prediagnostic anthropometric measures and risk of pancreatic
cancer. PanScan applied a nested case-control study design and included
2170 cases and 2209 control subjects. Odds ratios (ORs) and 95%
confidence intervals (CIs) were estimated using unconditional logistic
regression for cohort-specific quartiles of body mass index (BMI
[calculated as weight in kilograms divided by height in meters
squared]), weight, height, waist circumference, and waist to hip ratio
as well as conventional BMI categories (underweight, <18.5; normal
weight, 18.5-24.9; overweight, 25.0-29.9; obese, 30.0-34.9; and severely
obese, >= 35.0). Models were adjusted for potential confounders.
Results: In all of the participants, a positive association between
increasing BMI and risk of pancreatic cancer was observed (adjusted OR
for the highest vs lowest BMI guartile, 1.33; 95% Cl, 1.12-1.58;
P-trend<.001). In men, the adjusted OR for pancreatic cancer for the
highest vs lowest quartile of BMI was 1.33 (95% Cl, 1.04-1.69;
P-trend<.03), and in women it was 1.34 (95% Cl, 1.05-1.70;
P-trend=.01). Increased waist to hip ratio was associated with increased
risk of pancreatic cancer in women (adjusted OR for the highest vs
lowest quartile, 1.87; 95% Cl, 1.31-2.69; P-trend=.003) but less so in
men.
Conclusions: These findings provide strong support for a positive
association between BMI and pancreatic cancer risk. In addition,
centralized fat distribution may increase pancreatic cancer risk,
especially in women. Arch Intern Med. 2010;170(9):791 -802
ER -