TY - JOUR
TI - Simvastatin lowers reactive oxygen species level by Nrf2 activation via
PI3K/Akt pathway
AU - Chartoumpekis, Dionysios
AU - Ziros, Panos G.
AU - Psyrogiannis,
AU - Agathoklis
AU - Kyriazopoulou, Venetsana
AU - Papavassiliou, Athanasios G.
AU - and Habeos, Ioannis G.
JO - Biochemical and Biophysical Research Communications
PY - 2010
VL - 396
TODO - 2
SP - 463-466
PB - ACADEMIC PRESS INC ELSEVIER SCIENCE
SN - 0006-291X, 1090-2104
TODO - 10.1016/j.bbrc.2010.04.117
TODO - Nrf2; Simvastatin; Reactive oxygen species; HMG-CoA reductase
inhibitors; PI3K/Akt
TODO - The beneficial effects of HMG-CoA (3-hydroxy-3-methyl-glutaryl-CoA)
reductase inhibitors (statins) have been attributed not only to their
cholesterol lowering effect but also to their pleiotropic actions and
especially to their anti-oxidant activity. Nrf2 (NF-E2-related factor 2)
is a transcription factor that orchestrates the transcriptional response
of cells to oxidative stressors and electrophilic xenobiotics. In this
study, primary mouse embryonic fibroblasts from wild type or Nrf2 knock
out C57B16J mice and ST-2 cells were used to investigate the implication
of Nrf2 in the mediation of the anti-oxidant effects of statins and the
possible involvement of PI3K/Akt pathway in this process. We show for
the first time that simvastatin lowers reactive oxygen species (ROS) by
activating Nrf2 through the PI3K/Akt pathway. (C) 2010 Elsevier Inc. All
rights reserved.
ER -