TY - JOUR
TI - B-cell chronic lymphocytic leukemia risk in association with serum
leptin and adiponectin: a case-control study in Greece
AU - Dalamaga, Maria
AU - Crotty, Bradley H.
AU - Fargnoli, Jessica and
AU - Papadavid, Evangelia
AU - Lekka, Antigoni
AU - Triantafilli, Maria and
AU - Karmaniolas, Konstantinos
AU - Migdalis, Ilias
AU - Dionyssiou-Asteriou,
AU - Amalia
AU - Mantzoros, Christos S.
JO - Cancer Causes and Control
PY - 2010
VL - 21
TODO - 9
SP - 1451-1459
PB - Springer-Verlag
SN - 0957-5243, 1573-7225
TODO - 10.1007/s10552-010-9573-y
TODO - Adiponectin; Leptin; Adipokine; Chronic lymphocytic leukemia; Obesity
TODO - Aim Leptin and adiponectin are two well-studied adipokines in relation
to malignancies. In this study, we examined the association between
leptin/adiponectin and risk of B-cell chronic lymphocytic leukemia
(B-CLL), as well as the relationships between adipokines and several
established prognostic factors of B-CLL.
Methods Ninety-five patients with incident B-CLL and 95 hospital
controls matched on age and gender were studied between 2001 and 2007,
and blood samples were collected. Leptin, total and high molecular
weight adiponectin, and prognostic markers of B-CLL were determined.
Results Cases had a higher body mass index (BMI) than controls (p =
0.01) and lower levels of leptin (p < 0.01). Significantly more cases
than controls presented a family history of lymphohematopoietic cancer
(LHC) (p = 0.01). Higher serum leptin levels were associated with lower
risk of B-CLL adjusting for age, gender, family history of LHC, BMI and
serum adiponectin; the multivariate odds ratio comparing highest to
lowest tertile was 0.05 (95% CI 0.01-0.29, p trend < 0.001);
Adiponectin was not significantly different between cases and controls.
Conclusion Leptin was found to be inversely associated with risk of CLL
but in contrast to prior studies of CLL and hematologic malignancies,
this study found no significant association between CLL and adiponectin.
ER -