TY - JOUR
TI - Oral contraceptives, reproductive history and risk of colorectal cancer
in the European Prospective Investigation into Cancer and Nutrition
AU - Tsilidis, K. K.
AU - Allen, N. E.
AU - Key, T. J.
AU - Bakken, K.
AU - Lund,
AU - E.
AU - Berrino, F.
AU - Fournier, A.
AU - Olsen, A.
AU - Tjonneland, A. and
AU - Overvad, K.
AU - Boutron-Ruault, M-C
AU - Clavel-Chapelon, F.
AU - Byrnes,
AU - G.
AU - Chajes, V.
AU - Rinaldi, S.
AU - Chang-Claude, J.
AU - Kaaks, R. and
AU - Bergmann, M.
AU - Boeing, H.
AU - Koumantaki, Y.
AU - Stasinopoulou, G. and
AU - Trichopoulou, A.
AU - Palli, D.
AU - Tagliabue, G.
AU - Panico, S. and
AU - Tumino, R.
AU - Vineis, P.
AU - Bueno-de-Mesquita, H. B.
AU - van
AU - Duijnhoven, F. J. B.
AU - van Gils, C. H.
AU - Peeters, P. H. M. and
AU - Rodriguez, L.
AU - Gonzalez, C. A.
AU - Sanchez, M-J
AU - Chirlaque, M-D
AU - and Barricarte, A.
AU - Dorronsoro, M.
AU - Borgquist, S.
AU - Manjer, J.
AU - and van Guelpen, B.
AU - Hallmans, G.
AU - Rodwell, S. A.
AU - Khaw, K-T
AU - and Norat, T.
AU - Romaguera, D.
AU - Riboli, E.
JO - British Journal of Cancer
PY - 2010
VL - 103
TODO - 11
SP - 1755-1759
PB - Nature Publishing Group
SN - 0007-0920, 1532-1827
TODO - 10.1038/sj.bjc.6605965
TODO - oral contraceptives; reproductive history; colorectal cancer; cohort
study
TODO - BACKGROUND: Oral contraceptive use and reproductive factors may initiate
long-term changes to the hormonal milieu and thereby, possibly influence
colorectal cancer risk.
METHODS: We examined the association of hormonal and reproductive
factors with risk of colorectal cancer among 337 802 women in the
European Prospective Investigation into Cancer and Nutrition, of whom
1878 developed colorectal cancer.
RESULTS: After stratification for center and age, and adjustment for
body mass index, smoking, diabetes mellitus, physical activity and
alcohol consumption, ever use of oral contraceptives was marginally
inversely associated with colorectal cancer risk (hazard ratio (HR),
0.92; 95% confidence interval (CI), 0.83-1.02), although this
association was stronger among post-menopausal women (HR, 0.84; 95% CI:
0.74-0.95). Duration of oral contraceptive use and reproductive factors,
including age at menarche, age at menopause, type of menopause, ever
having an abortion, parity, age at first full-term pregnancy and
breastfeeding, were not associated with colorectal cancer risk.
CONCLUSION: Our findings provide limited support for a potential inverse
association between oral contraceptives and colorectal cancer risk.
British Journal of Cancer (2010) 103, 1755-1759.
doi:10.1038/sj.bjc.6605965 www.bjcancer.com Published online 2 November
2010 (C) 2010 Cancer Research UK
ER -