TY - JOUR
TI - Effects of Prolonged Warm and Cold Ischemia in a Solitary Kidney Animal
Model after Partial Nephrectomy: An Ultrastructural Investigation
AU - Tyritzis, Stavros I.
AU - Zachariades, Michael
AU - Evangelou, Kostas and
AU - Gorgoulis, Vassilis G.
AU - Kyroudi-Voulgari, Aspasia
AU - Pavlakis, Kitty
AU - and Troupis, Theodoros G.
AU - Constantinides, Constantinos A.
JO - Ultrastructural Pathology
PY - 2011
VL - 35
TODO - 2
SP - 60-65
PB - Taylor and Francis Inc.
SN - 0191-3123, 1521-0758
TODO - 10.3109/01913123.2010.542880
TODO - Electron microscopy; Ischemia-reperfusion injury; Partial nephrectomy;
Rabbit; Solitary kidney
TODO - Ischemia–reperfusion injury can be detrimental to the solitary kidney,
especially when it is accompanied by ablation. To the authors”
knowledge, the effects of partial nephrectomy with prolonged application
of ischemia have never been described at the ultrastructural level.
Therefore, the authors used an animal model and focused on putative
structural effects in the glomerular basement membrane and the
podocytes. They demonstrate the advantageous role of cold ischemia, even
in up to 120 min. In contrast, more than 60 min of warm ischemia leads
to catastrophic lesions in all the cellular structures, as is reflected
by mortality due to acute renal failure.</.
ER -