TY - JOUR
TI - C-Reactive Protein, Interleukin 6, and N-Terminal Pro-Brain Natriuretic
Peptide Following Cardioversion of Atrial Fibrillation: Is There a Role
of Biomarkers in Arrhythmia Recurrence?
AU - Psychari, Stavroula N.
AU - Chatzopoulos, Dionyssios
AU - Iliodromitis,
AU - Efstathios K.
AU - Apostolou, Thomas S.
AU - Kremastinos, Dimitrios T.
JO - International Angiology
PY - 2011
VL - 62
TODO - 4
SP - 310-316
PB - SAGE Publications Inc.
SN - 0392-9590
TODO - 10.1177/0003319710382418
TODO - atrial fibrillation; natriuretic peptides; inflammation; C-reactive
protein
TODO - Aims: We investigated the role of high-sensitivity C-reactive protein
(hsCRP), interleukin 6 (IL-6), and N-terminal pro-brain natriuretic
peptide (NTpro-BNP), in atrial fibrillation (AF) recurrence rate.
Methods: A total of 80 patients with first AF episode were studied
prospectively. Echocardiography (ECG), Holter ECG, and measurements of
hsCRP, IL-6, and NTpro-BNP were performed immediately post conversion
and at 1 month. Results: Recurrence was positively related to left
atrial volume (P < .001), with no difference in NTpro-BNP, hsCRP, and
IL-6. Decreased NTpro-BNP was observed in all at 1 month (P < .001, F =
63.4) and was positively related to left atrial volume (P < .01). In the
lone AF subgroup, NTpro-BNP was lower and dropped significantly at 1
month (interaction F = 6.53, P < .01). Conclusions: Atrial volume was
related to AF recurrence, whereas hsCRP, IL-6, and NTpro-BNP were not
reliable for AF relapse. Relation of NTpro-BNP to left atrial volume
could indicate a role in the atrial remodeling process.
ER -