TY - JOUR
TI - Brown Adipose Tissue Responds to Cold and Adrenergic Stimulation by
Induction of FGF21
AU - Chartoumpekis, Dionysios V.
AU - Habeos, Ioannis G.
AU - Ziros, Panos G.
AU - and Psyrogiannis, Agathoklis I.
AU - Kyriazopoulou, Venetsana E. and
AU - Papavassiliou, Athanasios G.
JO - Current Molecular Medicine
PY - 2011
VL - 17
TODO - 7-8
SP - 736-740
PB - Springer-Verlag
SN - 1566-5240
TODO - 10.2119/molmed.2011.00075
TODO - null
TODO - Fibroblast growth factor-21 (FGF21) is a pleiotropic protein involved in
glucose, lipid metabolism and energy homeostasis, with main tissues of
expression being the liver and adipose tissue. Brown adipose tissue
(BAT) is responsible for cold-induced thermogenesis in rodents. The role
of FGF21 in BAT biology has not been investigated. In the present study,
wild-type C57BL/6J mice as well as a brown adipocyte cell line were used
to explore the potential role of cold exposure and beta 3-adrenergic
stimulation in the expression of FGF21 in BAT. Our results demonstrate
that short-term exposure to cold, as well as beta 3-adrenergic
stimulation, causes a significant induction of FGF21 mRNA levels in BAT,
without a concomitant increase in FGF21 plasma levels. This finding
opens new routes for the potential use of pharmaceuticals that could
induce FGF21 and, hence, activate BAT thermogenesis. (C) 2011 The
Feinstein Institute for Medical Research, www.feinsteininstitute.org
ER -