TY - JOUR
TI - Anthropometric Measures, Physical Activity, and Risk of Glioma and
Meningioma in a Large Prospective Cohort Study
AU - Michaud, Dominique S.
AU - Bove, Gerald
AU - Gallo, Valentina and
AU - Schlehofer, Brigitte
AU - Tjonneland, Anne
AU - Olsen, Anja
AU - Overvad,
AU - Kim
AU - Dahm, Christina C.
AU - Teucher, Brigit
AU - Boeing, Heiner and
AU - Steffen, Annika
AU - Trichopoulou, Antonia
AU - Bamia, Christina and
AU - Kyrozis, Andreas
AU - Sacerdote, Carlotta
AU - Agnoli, Claudia
AU - Palli,
AU - Domenico
AU - Tumino, Rosario
AU - Mattiello, Amalia and
AU - Bueno-de-Mesquita, H. Bas
AU - Peeters, Petra H. M.
AU - May, Anne M. and
AU - Barricarte, Aurelio
AU - Chirlaque, Maria-Dolores
AU - Dorronsoro, Miren
AU - and Jose Sanchez, Maria
AU - Rodriguez, Laudina
AU - Duell, Eric J. and
AU - Hallmans, Goran
AU - Melin, Beatrice S.
AU - Manjer, Jonas
AU - Borgquist,
AU - Signe
AU - Khaw, Kay-Tee
AU - Wareham, Nick
AU - Allen, Naomi E. and
AU - Travis, Ruth C.
AU - Romieu, Isabelle
AU - Vineis, Paolo
AU - Riboli, Elio
JO - Cancer Prevention Research
PY - 2011
VL - 4
TODO - 9
SP - 1385-1392
PB - AMER ASSOC CANCER RESEARCH
SN - 1940-6207, 1940-6215
TODO - 10.1158/1940-6207.CAPR-11-0014
TODO - null
TODO - Body fatness has been associated with increased risk of a number of
hormone-dependent cancers. Recent studies suggest that body mass index
(BMI) may be related to meningiomas, which are more common in women than
men, and for which estrogens are believed to play a role. Using data
from a large European propective cohort, 203 incident cases of
meningioma and 340 cases of glioma were included in the analysis for
measures of body fat, height, and physical activity among 380,775
participants. All analyses were conducted using Cox proportional hazards
model and controlling for age, sex, country, and education. A 71%
increase in risk of meningioma was observed among men and women in the
top quartile of waist circumference (HR = 1.71, 95% CI = 1.08-2.73,
P-trend = 0.01). A positive association was also observed for BMI and
meningioma (HR = 1.48, 95% CI = 0.98-2.23, for BMI >= 30 compared with
a BMI of 20-24.9, P-trend = 0.05). An association with height and
meningioma was also suggestive (HR = 1.24, 95% 0.96-1.51, for each 10
cm increase). In contrast, no associations were observed for height and
different measures of body fat and risk of glioma. Physical activity was
not related to either type of brain tumors. Results from this study
support an increase in risk of meningioma with higher body fatness among
both men and women. No association was observed between anthropometric
measures and risk of glioma. Cancer Prev Res; 4(9); 1385-92. (C) 2011
AACR.
ER -