TY - JOUR
TI - Common Breast Cancer Susceptibility Loci Are Associated with
Triple-Negative Breast Cancer
AU - Stevens, Kristen N.
AU - Vachon, Celine M.
AU - Lee, Adam M.
AU - Slager,
AU - Susan
AU - Lesnick, Timothy
AU - Olswold, Curtis
AU - Fasching, Peter A.
AU - and Miron, Penelope
AU - Eccles, Diana
AU - Carpenter, Jane E.
AU - Godwin,
AU - Andrew K.
AU - Ambrosone, Christine
AU - Winqvist, Robert
AU - Brauch,
AU - Hiltrud
AU - Schmidt, Marjanka K.
AU - Cox, Angela
AU - Cross, Simon S. and
AU - Sawyer, Elinor
AU - Hartmann, Arndt
AU - Beckmann, Matthias W. and
AU - Schulz-Wendtland, Ruediger
AU - Ekici, Arif B.
AU - Tapper, William J. and
AU - Gerty, Susan M.
AU - Durcan, Lorraine
AU - Graham, Nikki
AU - Hein, Rebecca
AU - and Nickels, Stephan
AU - Flesch-Janys, Dieter
AU - Heinz, Judith and
AU - Sinn, Hans-Peter
AU - Konstantopoulou, Irene
AU - Fostira, Florentia and
AU - Pectasides, Dimitrios
AU - Dimopoulos, Athanasios M.
AU - Fountzilas,
AU - George
AU - Clarke, Christine L.
AU - Balleine, Rosemary
AU - Olson, Janet
AU - E.
AU - Fredericksen, Zachary
AU - Diasio, Robert B.
AU - Pathak, Harsh and
AU - Ross, Eric
AU - Weaver, JoEllen
AU - Ruediger, Thomas
AU - Forsti, Asta and
AU - Duennebier, Thomas
AU - Ademuyiwa, Foluso
AU - Kulkarni, Swati and
AU - Pylkaes, Katri
AU - Jukkola-Vuorinen, Arja
AU - Ko, Yon-Dschun
AU - Van
AU - Limbergen, Erik
AU - Janssen, Hilde
AU - Peto, Julian
AU - Fletcher, Olivia
AU - and Giles, Graham G.
AU - Baglietto, Laura
AU - Verhoef, Senno and
AU - Tomlinson, Ian
AU - Kosma, Veli-Matti
AU - Beesley, Jonathan
AU - Greco,
AU - Dario
AU - Blomqvist, Carl
AU - Irwanto, Astrid
AU - Liu, Jianjun and
AU - Blows, Fiona M.
AU - Dawson, Sarah-Jane
AU - Margolin, Sara
AU - Mannermaa,
AU - Arto
AU - Martin, Nicholas G.
AU - Montgomery, Grant W.
AU - Lambrechts,
AU - Diether
AU - Silva, Isabel dos Santos
AU - Severi, Gianluca
AU - Hamann,
AU - Ute
AU - Pharoah, Paul
AU - Easton, Douglas F.
AU - Chang-Claude, Jenny and
AU - Yannoukakos, Drakoulis
AU - Nevanlinna, Heli
AU - Wang, Xianshu
AU - Couch,
AU - Fergus J.
AU - GENICA Consortium
JO - Current Cancer Research
PY - 2011
VL - 71
TODO - 19
SP - 6240-6249
PB - AMER ASSOC CANCER RESEARCH
SN - null
TODO - 10.1158/0008-5472.CAN-11-1266
TODO - null
TODO - Triple-negative breast cancers are an aggressive subtype of breast
cancer with poor survival, but there remains little known about the
etiologic factors that promote its initiation and development. Commonly
inherited breast cancer risk factors identified through genome-wide
association studies display heterogeneity of effect among breast cancer
subtypes as defined by the status of estrogen and progesterone
receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22
common breast cancer susceptibility variants were investigated in 2,980
Caucasian women with triple-negative breast cancer and 4,978 healthy
controls. We identified six single-nucleotide polymorphisms, including
rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737
(RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly
associated with the risk of triple-negative breast cancer. Together, our
results provide convincing evidence of genetic susceptibility for
triple-negative breast cancer. Cancer Res; 71(19); 6240-9. (C)2011 AACR.
ER -