TY - JOUR
TI - Genetic variability of the forkhead box O3 and prostate cancer risk in
the European Prospective Investigation on Cancer
AU - Campa, Daniele
AU - Huesing, Anika
AU - Dostal, Lucie
AU - Stein, Angelika
AU - and Drogan, Dagmar
AU - Boeing, Heiner
AU - Tjonneland, Anne
AU - Roswall,
AU - Nina
AU - Ostergaard, Jane Nautrup
AU - Overvad, Kim
AU - Rodriguez,
AU - Laudina
AU - Bonet, Catalina
AU - Sanchez, Maria-Jose
AU - Larranaga, Nerea
AU - and Maria Huerta, Jose
AU - Ardanaz, Eva
AU - Khaw, Kay-Tee
AU - Wareham,
AU - Nicholas
AU - Travis, Ruth C.
AU - Allen, Naomi E.
AU - Trichopoulou,
AU - Antonia
AU - Zylis, Dimosthenis
AU - Karapetyan, Tina
AU - Palli, Domenico
AU - and Sieri, Sabina
AU - Tumino, Rosario
AU - Vineis, Paolo and
AU - Bueno-De-Mesquita, H. Bas
AU - Lenner, Per
AU - Johansson, Mattias and
AU - Jenab, Mazda
AU - Cox, David
AU - Siddiq, Afshan
AU - Kaaks, Rudolf and
AU - Canzian, Federico
JO - ONCOLOGY REPORTS
PY - 2011
VL - 26
TODO - 4
SP - 979-986
PB - SPANDIDOS PUBL LTD
SN - 1021-335X
TODO - 10.3892/or.2011.1359
TODO - genetic variability; forkhead box; prostate cancer
TODO - Forkhead box O3 (FOXO3) has a wide range of functions: it promotes tumor
suppression, cell cycle arrest, repair of damaged DNA, detoxification of
reactive oxygen species, apoptosis and plays a pivotal role in promoting
longevity. FOXO3 is a key downstream target of the PI3K-Akt pathway in
response to cellular stimulation by growth factors or insulin and has
been proposed as a bridge between ageing and tumor suppression. Three
SNPs in the FOXO3 gene (rs3800231, rs9400239 and rs479744) that have
been shown to be strongly and consistently associated with longevity,
were examined in relation to PC risk in a case control study of 1571
incident PC cases and 1840 controls nested within the European
Prospective Investigation into Cancer and Nutrition (EPIC). There was no
statistically significant association between the SNPs and PC risk
regardless of the model of inheritance (dominant, codominant and
recessive). The associations were not modified by disease
aggressiveness, circulating levels of steroid sex hormones, or IGFs or
BMI. We conclude that polymorphisms in the FOXO3 gene that are
associated with longevity are not major risk factors for PC risk, in
this population of Caucasian men.
ER -