TY - JOUR
TI - Endogenous Sex Steroids and Risk of Cervical Carcinoma: Results from the
EPIC Study
AU - Rinaldi, Sabina
AU - Plummer, Martyn
AU - Biessy, Carine
AU - Castellsague,
AU - Xavier
AU - Overvad, Kim
AU - Kjaer, Susanne Krueger
AU - Tjonneland, Anne
AU - and Clavel-Chapelon, Francoise
AU - Chabbert-Buffet, Nathalie and
AU - Mesrine, Sylvie
AU - Lukanova, Annekatrin
AU - Kaaks, Rudolf
AU - Weikert,
AU - Cornelia
AU - Boeing, Heiner
AU - Trichopoulou, Antonia
AU - Lagiou, Pagona
AU - and Trichopoulos, Dimitrios
AU - Palli, Domenico
AU - Agnoli, Claudia and
AU - Tumino, Rosario
AU - Vineis, Paolo
AU - Panico, Salvatore and
AU - Bueno-de-Mesquita, Bas
AU - van Kranen, Henk J.
AU - Peeters, Petra H. M.
AU - and Bakken, Kjersti
AU - Lund, Eiliv
AU - Gram, Inger Torhild and
AU - Rodriguez, Laudina
AU - Bosch, F. Xavier
AU - Sanchez, Maria-Jose and
AU - Dorronsoro, Miren
AU - Navarro, Carmen
AU - Barricarte Gurrea, Aurelio and
AU - Kjellberg, Lennart
AU - Dillner, Joakim
AU - Manjer, Jonas
AU - Butt, Salma
AU - and Khaw, Kay-Tee
AU - Wareham, Nicholas
AU - Allen, Naomi E.
AU - Travis,
AU - Ruth
AU - Romieu, Isabelle
AU - Ferrari, Pietro
AU - Riboli, Elio and
AU - Franceschi, Silvia
JO - Cancer Epidemiology, Biomarkers & Prevention
PY - 2011
VL - 20
TODO - 12
SP - 2532-2540
PB - AMER ASSOC CANCER RESEARCH
SN - 1055-9965, 1538-7755
TODO - 10.1158/1055-9965.EPI-11-0753
TODO - null
TODO - Background: Epidemiologic data and animal models suggest that, despite
the predominant role of human papillomavirus infection, sex steroid
hormones are also involved in the etiology of invasive cervical
carcinoma (ICC).
Methods: Ninety-nine ICC cases, 121 cervical intraepithelial neoplasia
grade 3 (CIN3) cases and 2 control women matched with each case for
center, age, menopausal status and blood collection-related variables,
were identified in the European Prospective Investigation into Cancer
and Nutrition (EPIC) study. Circulating levels of testosterone (T) and
estradiol (E-2); dehydroepiandrosterone sulfate (DHEAS); progesterone
(premenopausal women); and sex hormone-binding globulin (SHBG) were
measured using immunoassays. Levels of free (f) T and E-2 were
calculated from absolute concentrations of T, E-2, and SHBG. Odds ratios
(ORs) and 95% confidence intervals (CI) were computed using regularized
conditional logistic regression.
Results: Among premenopausal women, associations with ICC were observed
for fT (OR for highest vs. lowest tertile 5.16, 95% CI, 1.50-20.1).
SHBG level was associated with a significant downward trend in ICC risk.
T, E-2, fE(2), and DHEAS showed nonsignificant positive association with
ICC. Progesterone was uninfluential. Among postmenopausal women,
associations with ICC were found for T (OR 3.14; 95% CI, 1.21-9.37),
whereas E-2 and fT showed nonsignificant positive association. SHBG
level was unrelated to ICC risk in postmenopausal women. No associations
between any hormone and CIN3 were detected in either pre- or
postmenopausal women.
Conclusions: Our findings suggest for the first time that T and possibly
E-2 may be involved in the etiology of ICC.
Impact: The responsiveness of cervical tumors to hormone modulators is
worth exploring. Cancer Epidemiol Biomarkers Prev; 20(12); 2532-40. (C)
2011 AACR.
ER -