TY - JOUR
TI - TGF-beta signalling in colon carcinogenesis
AU - Lampropoulos, Pavlos
AU - Zizi-Sermpetzoglou, Adamantia
AU - Rizos, Spyros
AU - and Kostakis, Alkiviadis
AU - Nikiteas, Nikolaos
AU - Papavassiliou,
AU - Athanasios G.
JO - Cancer Letter
PY - 2012
VL - 314
TODO - 1
SP - 1-7
PB - Elsevier Ireland Ltd
SN - null
TODO - 10.1016/j.canlet.2011.09.041
TODO - TGF-beta signalling pathway; Colorectal cancer (CRC); Targeted therapy
TODO - Colorectal cancer remains the most common cancer and the second leading
cause of cancer mortality in Europe. There are a number of pathways that
have been implicated in colorectal carcinogenesis, including TGF-beta
(TGF-beta)/Smad signalling pathway. The TGF-beta pathway is involved in
several biological processes, including cell proliferation,
differentiation, migration and apoptosis. Here we review the role of
TGF-beta signalling cascade in colorectal carcinogenesis and provide
some new molecular insights that may aid efforts towards targeted
antitumor therapies. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
ER -