TY - JOUR
TI - IL-9 Induces VEGF Secretion from Human Mast Cells and IL-9/IL-9 Receptor
Genes Are Overexpressed in Atopic Dermatitis
AU - Sismanopoulos, Nikolaos
AU - Delivanis, Danae A.
AU - Alysandratos,
AU - Konstantinos D.
AU - Angelidou, Asimenia
AU - Vasiadi, Magdalini and
AU - Therianou, Anastasia
AU - Theoharides, Theoharis C.
JO - PLOS ONE
PY - 2012
VL - 7
TODO - 3
SP - null
PB - Public Library of Science
SN - null
TODO - 10.1371/journal.pone.0033271
TODO - null
TODO - Interleukin 9 (IL-9) has been implicated in mast cell-related
inflammatory diseases, such as asthma, where vascular endothelial growth
factor (VEGF) is involved. Here we report that IL-9 (10-20 ng/ml)
induces gene expression and secretion of VEGF from human LAD2. IL-9 does
not induce mast cell degranulation or the release of other mediators
(IL-1, IL-8, or TNF). VEGF production in response to IL-9 involves
STAT-3 activation. The effect is inhibited (about 80%) by the STAT-3
inhibitor, Stattic. Gene-expression of IL-9 and IL-9 receptor is
significantly increased in lesional skin areas of atopic dermatitis (AD)
patients as compared to normal control skin, while serum IL-9 is not
different from controls. These results imply that functional
interactions between IL-9 and mast cells leading to VEGF release
contribute to the initiation/propagation of the pathogenesis of AD, a
skin inflammatory disease.
ER -