TY - JOUR
TI - Review of the molecular profile and modern prognostic markers for
gastric lymphoma: How do they affect clinical practice?
AU - Alevizos, Leonidas
AU - Gomatos, Ilias P.
AU - Smparounis, Spyridon and
AU - Konstadoulakis, Manousos M.
AU - Zografos, Georgios
JO - Canadian Journal of Surgery
PY - 2012
VL - 55
TODO - 2
SP - 117-124
PB - CMA-CANADIAN MEDICAL ASSOC
SN - 0008-428X, 1488-2310
TODO - 10.1503/cjs.002310
TODO - null
TODO - Primary gastric lymphoma is a rare cancer of the stomach with an
indeterminate prognosis. Recently, a series of molecular prognostic
markers has been introduced to better describe this clinical entity.
This review describes the clinical importance of several oncogenes,
apoptotic genes and chromosomal mutations in the initiation and progress
of primary non-Hodgkin gastric lymphoma and their effect on patient
survival. We also outline the prognostic clinical importance of certain
cellular adhesion molecules, such as ICAM and PECAM-1, in patients with
gastric lymphoma, and we analyze the correlation of these molecules with
apoptosis, angiogenesis, tumour growth and metastatic potential. We also
focus on the host-immune response and the impact of Helicobacter pylori
infection on gastric lymphoma development and progression. Finally, we
explore the therapeutic methods currently available for gastric
lymphoma, comparing the traditional invasive approach with more recent
conservative options, and we stress the importance of the application of
novel molecular markers in clinical practice.
ER -