TY - JOUR
TI - Biomarkers of Oxidative Stress and Risk of Developing Colorectal Cancer:
A Cohort-nested Case-Control Study in the European Prospective
Investigation Into Cancer and Nutrition
AU - Leufkens, Anke M.
AU - van Duijnhoven, Franzel J. B.
AU - Woudt, Sjoukje
AU - H. S.
AU - Siersema, Peter D.
AU - Jenab, Mazda
AU - Jansen, Eugene H. J.
AU - M.
AU - Pischon, Tobias
AU - Tjonneland, Anne
AU - Olsen, Anja
AU - Overvad,
AU - Kim
AU - Boutron-Ruault, Marie Christine
AU - Clavel-Chapelon, Francoise
AU - and Morois, Sophie
AU - Palli, Domenico
AU - Pala, Valeria
AU - Tumino,
AU - Rosario
AU - Vineis, Paolo
AU - Panico, Salvatore
AU - Kaaks, Rudolf and
AU - Lukanova, Annekatrin
AU - Boeing, Heiner
AU - Aleksandrova, Krasimira and
AU - Trichopoulou, Antonia
AU - Trichopouios, Dimitrios
AU - Dilis, Vardis and
AU - Peeters, Petra H.
AU - Skeie, Guri
AU - Gonzalez, Carlos A. and
AU - Argueelles, Marcial
AU - Sanchez, Maria-Jose
AU - Dorronsoro, Miren and
AU - Huerta, Jose Maria
AU - Ardanaz, Eva
AU - Hallmans, Goran
AU - Palmqvist,
AU - Richard
AU - Khaw, Kay-Tee
AU - Wareham, Nick
AU - Allen, Naomi E. and
AU - Crowe, Francesca L.
AU - Fedirko, Veronika
AU - Norat, Teresa
AU - Riboli,
AU - Elio
AU - Bueno-de-Mesquita, H. Bas
JO - American Journal of Epidemiology
PY - 2012
VL - 175
TODO - 7
SP - 653-663
PB - OXFORD UNIV PRESS INC
SN - 0002-9262, 1476-6256
TODO - 10.1093/aje/kwr418
TODO - biological markers; case-control studies; colorectal neoplasms;
oxidative stress
TODO - Oxidative stress has been shown to play an important role in
carcinogenesis, but prospective evidence for an association between
biomarkers of oxidative stress and colorectal cancer (CRC) risk is
limited. The authors investigated the association between prediagnostic
serum levels of oxidative stress indicators (i.e., reactive oxygen
metabolites (ROM) and ferric reducing ability of plasma (FRAP)) and CRC
risk. This was examined in a nested case-control study (1,064 CRC cases,
1,064 matched controls) in the European Prospective Investigation Into
Cancer and Nutrition cohort (1992-2003). Incidence rate ratios and 95%
confidence intervals were calculated using conditional logistic
regression analyses. ROM were associated with overall CRC risk (highest
tertile vs. lowest: adjusted incidence rate ratio (IRRadj) = 1.91, 95%
confidence interval (CI): 1.47, 2.48), proximal (IRRadj = 1.89, 95% CI:
1.06, 3.36) and distal (IRRadj = 2.31, 95% CI: 1.37, 3.89) colon
cancer, and rectal cancer (IRRadj = 1.69, 95% CI: 1.05, 2.72). When
results were stratified by tertile of follow-up time, the association
remained significant only in participants with less than 2.63 years of
follow-up (IRRadj = 2.28, 95% CI: 1.78, 2.94; P-heterogeneity < 0.01).
FRAP was not associated with CRC risk. In conclusion, prediagnostic
serum ROM levels were associated with increased risk of CRC. However,
this association was seen only in subjects with relatively short
follow-up, suggesting that the association results from production of
reactive oxygen species by preclinical tumors.
ER -