TY - JOUR
TI - The pine-cone body: an intermediate structure between the cap mesenchyme
and the renal vesicle in the developing nod mouse kidney revealed by an
ultrastructural study
AU - Piludu, Marco
AU - Fanos, Vassilios
AU - Congiu, Terenzio
AU - Piras,
AU - Monica
AU - Gerosa, Clara
AU - Mocci, Cristina
AU - Fanni, Daniela and
AU - Nemolato, Sonia
AU - Muntoni, Sandro
AU - Iacovidou, Nicoletta
AU - Faa,
AU - Gavino
JO - Journal of Maternal-Fetal and Neonatal Medicine
PY - 2012
VL - 25
TODO - 5
SP - 72-75
PB - TAYLOR & FRANCIS LTD LONDON
SN - 1476-7058, 1476-4954
TODO - 10.3109/14767058.2012.714645
TODO - Electron microscopy; glomerulogenesis; nephrons; nephrogenesis
TODO - Nephrogenesis is mainly characterized by the interaction of two distinct
renal constituents, the ureteric bud and the metanephric mesenchyme. In
this paper we describe by means of light and electron microscopic
techniques the morphological events that take place during the early
stages of cap mesenchymal formation. Samples of normal renal tissue were
excised from newborn NOD mice and processed by standard light and
electron microscopy techniques. In all samples examined we detected the
presence of several cap mesenchymal aggregates in different stages of
differentiation. They varied from small solid nodules with few ovoid
cells to bigger pine-cone-like aggregates, characterized by a peculiar
distribution and morphology of their cellular constituents. Our data
highlight, for the first time, the presence of a specific cap
mesenchymal structure, the pine-cone body and show, at ultrastructural
level, how each cap aggregate epithelializes proceeding in stages from a
condensed mesenchymal aggregate to the renal vesicle, through the
intermediate “pine-cone body” stage.
ER -