TY - JOUR
TI - Leptin and Soluble Leptin Receptor in Risk of Colorectal Cancer in the
European Prospective Investigation into Cancer and Nutrition Cohort
AU - Aleksandrova, Krasimira
AU - Boeing, Heiner
AU - Jenab, Mazda and
AU - Bueno-de-Mesquita, H. Bas
AU - Jansen, Eugene
AU - van Duijnhoven, Franzel
AU - J. B.
AU - Rinaldi, Sabina
AU - Fedirko, Veronika
AU - Romieu, Isabelle and
AU - Riboli, Elio
AU - Gunter, Marc J.
AU - Westphal, Sabine
AU - Overvad, Kim
AU - and Tjonneland, Anne
AU - Halkjaer, Jytte
AU - Racine, Antoine and
AU - Boutron-Ruault, Marie-Christine
AU - Clavel-Chapelon, Francoise and
AU - Kaaks, Rudolf
AU - Lukanova, Annekatrin
AU - Trichopoulou, Antonia and
AU - Lagiou, Pagona
AU - Trichopoulos, Dimitrios
AU - Mattiello, Amalia and
AU - Pala, Valeria
AU - Palli, Domenico
AU - Tumino, Rosario
AU - Vineis, Paolo
AU - and Buckland, Genevieve
AU - Sanchez, Maria-Jose
AU - Amiano, Pilar and
AU - Maria Huerta, Jose
AU - Barricarte, Aurelio
AU - Menendez, Virginia and
AU - Peeters, Petra H.
AU - Soderberg, Stefan
AU - Palmqvist, Richard and
AU - Allen, Naomi E.
AU - Crowe, Francesca L.
AU - Khaw, Kay-Tee
AU - Wareham,
AU - Nickolas
AU - Pischon, Tobias
JO - Current Cancer Research
PY - 2012
VL - 72
TODO - 20
SP - 5328-5337
PB - AMER ASSOC CANCER RESEARCH
SN - null
TODO - 10.1158/0008-5472.CAN-12-0465
TODO - null
TODO - Leptin, a peptide hormone produced primarily by the adipocytes, is
hypothesized to play a role in the pathogenesis of colorectal cancer
(CRC). Soluble leptin receptor (sOB-R) may regulate leptin’s physiologic
functions; however its relation to CRC risk is unknown. This study
explored the association of leptin and sOB-R with risk of CRC in a
prospective nested case-control study within the European Prospective
Investigation into Cancer and Nutrition (EPIC) cohort. A total of 1,129
incident CRC cases (713 colon, 416 rectal) were matched within risk sets
to 1,129 controls. Conditional logistic regression was used to calculate
relative risks (RR) and 95% confidence intervals (CI). After
multivariable adjustment including body mass index (BMI), waist
circumference, and baseline leptin concentrations, sOB-R was strongly
inversely associated with CRC (RR comparing the highest quintile vs. the
lowest, 0.55; 95% CI, 0.40-0.76; P-trend = 0.0004) and colon cancer
(RR, 0.42; 95% CI, 0.28-0.63, P-trend = 0.0001); whereas no association
was seen for rectal cancer (RR adjusted for BMI and waist circumference,
0.83; 95% CI, 0.48-1.44, P-trend = 0.38). In contrast, leptin was not
associated with risk of CRC (RR adjusted for BMI and waist
circumference, 0.85; 95% CI, 0.56-1.29, P-trend = 0.23). Additional
adjustments for circulating metabolic biomarkers did not attenuate these
results. These novel findings suggest a strong inverse association
between circulating sOB-R and CRC risk, independent of obesity measures,
leptin concentrations, and other metabolic biomarkers. Further research
is needed to confirm the potentially important role of sOB-R in CRC
pathogenesis. Cancer Res; 72(20); 5328-37. (C) 2012 AACR.
ER -