TY - JOUR
TI - Risk factors for development of Clostridium difficile infection due to
BI/NAP1/027 strain: a meta-analysis
AU - Vardakas, Konstantinos Z.
AU - Konstantelias, Athanasios A.
AU - Loizidis,
AU - Giorgos
AU - Rafailidis, Petros I.
AU - Falagas, Matthew E.
JO - International Journal of Infectious Diseases
PY - 2012
VL - 16
TODO - 11
SP - E768-E773
PB - Elsevier Sci Ltd, Exeter, United Kingdom
SN - 1201-9712
TODO - 10.1016/j.ijid.2012.07.010
TODO - Clostridium difficile; Infection; BI/NAP1/027
TODO - Objective: To identify risk factors for the development of Clostridium
difficile infection (CDI) due to C. difficile BI/NAP1/027 strain.
Methods: PubMed and Scopus databases were searched for studies that
sought to identify risk factors for CDI due to the BI/NAP1/027 strain.
The technique of meta-analysis was applied.
Results: Five studies compared CDI BI/NAP1/027 patients to CDI patients
infected with non-BI/NAP1/027 strains, one compared CDI BI/NAP1/027
patients to non-CDI patients, and one provided data for both
comparisons. The meta-analysis showed that fluoroquinolones were
associated with a higher risk of CDI due to BI/NAP1/027 when compared to
non-BI/NAP1/027 CDI (odds ratio (OR) 1.96, 95% confidence interval
(95% CI) 1.37-2.80). A trend towards a lower risk for CDI due to
BI/NAP1/027 was observed with cephalosporins when compared to
non-BI/NAP1/027 CDI (OR 0.70, 95% CI 0.46-1.07). Prior macrolides were
not associated with a higher risk for CDI BI/NAP1/027 when compared with
non-BI/NAP1/027 CDI controls (OR 0.88, 95% CI 0.44-1.78). Clindamycin
administration was associated with a lower risk for CDI due to
BI/NAP1/027 when compared to non-BI/NAP1/027 CDI (OR 0.24, 95% CI
0.12-0.48). Age over 65 years was associated with an increased risk of
CDI BI/NAP1/027 compared to non-BI/NAP1/027 CDI (OR 1.77, 95% CI
1.31-2.38).
Conclusions: Fluoroquinolones and age over 65 years were associated with
a higher risk of CDI due to the BI/NAP1/027 strain. Clindamycin was
associated with a lower risk of CDI due to BI/NAP1/027. (C) 2012
International Society for Infectious Diseases. Published by Elsevier
Ltd. All rights reserved.
ER -