TY - JOUR
TI - Total and high-molecular weight adiponectin and risk of colorectal
cancer: the European Prospective Investigation into Cancer and Nutrition
Study
AU - Aleksandrova, Krasimira
AU - Boeing, Heiner
AU - Jenab, Mazda and
AU - Bueno-de-Mesquita, H. Bas
AU - Jansen, Eugene
AU - van Duijnhoven, Franzel
AU - J. B.
AU - Fedirko, Veronika
AU - Rinaldi, Sabina
AU - Romieu, Isabelle and
AU - Riboli, Elio
AU - Romaguera, Dora
AU - Westphal, Sabine
AU - Overvad, Kim
AU - and Tjonneland, Anne
AU - Boutron-Ruault, Marie Christine and
AU - Clavel-Chapelon, Francoise
AU - Kaaks, Rudolf
AU - Lukanova, Annekatrin
AU - and Trichopoulou, Antonia
AU - Lagiou, Pagona
AU - Trichopoulos, Dimitrios
AU - and Agnoli, Claudia
AU - Mattiello, Amalia
AU - Saieva, Calogero and
AU - Vineis, Paolo
AU - Tumino, Rosario
AU - Peeters, Petra H.
AU - Argueelles,
AU - Marcial
AU - Bonet, Catalina
AU - Sanchez, Maria-Jose
AU - Dorronsoro,
AU - Miren
AU - Huerta, Jose-Maria
AU - Barricarte, Aurelio
AU - Palmqvist,
AU - Richard
AU - Hallmans, Goran
AU - Khaw, Kay-Tee
AU - Wareham, Nick and
AU - Allen, Naomi E.
AU - Crowe, Francesca L.
AU - Pischon, Tobias
JO - Journal of Carcinogenesis
PY - 2012
VL - 33
TODO - 6
SP - 1211-1218
PB - Oxford University Press
SN - 1477-3163
TODO - 10.1093/carcin/bgs133
TODO - null
TODO - Adiponectin an adipose tissue-derived protein may provide a molecular
link between obesity and colorectal cancer (CRC), but evidence from
large prospective studies is limited. In particular, no epidemiological
study explored high-molecular weight (HMW) and non-HMW adiponectin
fractions in relation to CRC risk, despite them being hypothesized to
have differential biological activities, i.e. regulating insulin
sensitivity (HMW adiponectin) versus inflammatory response (non-HNW
adiponectin). In a prospective, nested case control study, we
investigated whether prediagnostic serum concentrations of total, HMW
and non-HMW adiponectin are associated with risk of CRC, independent of
obesity and other known CRC risk factors. A total of 1206 incident cases
(755 colon and 451 rectal) were matched to 1206 controls using
incidence-density sampling. In conditional logistic regression, adjusted
for dietary and lifestyle factors, total adiponectin and non-HMW
adiponectin concentrations were inversely associated with risk of CRC
[relative risk (RR) comparing highest versus lowest quintile = 0.71,
95% confidence interval (CI) = 0.53-0.95, P-trend = 0.03 for total
adiponectin and RR = 0.45, 95% Cl = 0.34-0.61, P-trend < 0.0001 for
non-HMW adiponectin] HMW adiponectin concentrations were not associated
with CRC risk (RR = 0.91, 95% Cl = 0.68-1.22, P-trend = 0.55). Non-HMW
adiponectin was associated with CRC risk even after adjustment for body
mass index and waist circumference (RR = 0.39, 95% CI = 0.26-0.60,
P-trend < 0.0001), whereas the association with total adiponectin was no
longer significant (RR = 0.81, 95% CI = 0.60A.09, P-trend = 0.23). When
stratified by cancer site, non-HMW adiponectin was inversely associated
with both colon and rectal cancer. These findings suggest an important
role of the relative proportion of non-HMW adiponectin in CRC
pathogenesis. Future studies are warranted to confirm these results and
to elucidate the underlying mechanisms.
ER -