TY - JOUR
TI - Cigarette smoking and risk of histological subtypes of epithelial
ovarian cancer in the EPIC cohort study
AU - Gram, Inger T.
AU - Lukanova, Annekatrin
AU - Brill, Ilene
AU - Braaten,
AU - Tonje
AU - Lund, Eiliv
AU - Lundin, Eva
AU - Overvad, Kim
AU - Tjonneland,
AU - Anne
AU - Clavel-Chapelon, Francoise
AU - Chabbert-Buffet, Nathalie and
AU - Bamia, Christina
AU - Trichopoulou, Antonia
AU - Zylis, Dimosthenis and
AU - Masala, Giovanna
AU - Berrino, Franco
AU - Galasso, Rocco
AU - Tumino,
AU - Rosario
AU - Sacerdote, Carlotta
AU - Gavrilyuk, Oxana
AU - Kristiansen,
AU - Steinar
AU - Rodriguez, Laudina
AU - Bonet, Catalina
AU - Maria Huerta,
AU - Jose
AU - Barricarte, Aurelio
AU - Sanchez, Maria-Jose
AU - Dorronsoro,
AU - Miren
AU - Jirstrom, Karin
AU - Almquist, Martin
AU - Idahl, Annika and
AU - Bueno-de-Mesquita, H. Bas
AU - Braem, Marie
AU - Onland-Moret, Charlotte
AU - and Tsilidis, Konstantinos K.
AU - Allen, Naomi E.
AU - Fedirko, Veronika
AU - and Riboli, E.
AU - Kaaks, Rudolf
JO - International Journal  of Cancer
PY - 2012
VL - 130
TODO - 9
SP - 2204-2210
PB - Wiley
SN - 0020-7136
TODO - 10.1002/ijc.26235
TODO - ovarian cancer; smoking; mucinous; serous; EPIC cohort
TODO - New data regarding a positive association between smoking and risk of
epithelial ovarian cancer (EOC), especially the mucinous tumor type, has
started to emerge. The purpose of this study was to examine the
association between different measures of smoking exposures and subtypes
of EOC in a large cohort of women from 10 European countries. The
European Prospective Investigation into Cancer and Nutrition (EPIC)
cohort is a multicenter prospective study initiated in 1992. The
questionnaires included data about dietary, lifestyle, and health
factors. Information about cigarette smoking was collected from
individuals in all participating countries. We used Cox proportional
hazard regression models to estimate hazard ratio (HR) of EOC overall
and serous, mucinous, and endometroid histological subtypes, with 95%
confidence intervals (CIs) associated with different measures of smoking
exposures adjusting for confounding variables. Altogether 836 incident
EOC cases were identified among 326,831 women. The tumors were
classified as 400 serous, 83 mucinous, 80 endometroid, 35 clear cell,
and 238 unspecified. Compared with never smokers, current smokers had a
significantly increased risk for mucinous tumors [HR = 1.85 (95% CI
1.083.16)] and those smoking more than 10 cigarettes per day had a
doubling in risk [HR = 2.25(95% CI 1.264.03)] as did those who had
smoked less than 15 pack-years of cigarettes [HR = 2.18 (95% CI
1.074.43)]. The results from the EPIC study add further evidence that
smoking increases risk of mucinous ovarian cancer and support the notion
that the effect of smoking varies according to histological subtype.
ER -