TY - JOUR
TI - Alcohol drinking and endometrial cancer risk in the European Prospective
Investigation into Cancer and Nutrition (EPIC) study
AU - Fedirko, Veronika
AU - Jenab, Mazda
AU - Rinaldi, Sabina
AU - Biessy,
AU - Carine
AU - Allen, Naomi E.
AU - Dossus, Laure
AU - Onland-Moret, N.
AU - Charlotte
AU - Schuetze, Madlen
AU - Tjonneland, Anne
AU - Hansen, Louise
AU - and Overvad, Kim
AU - Clavel-Chapelon, Francoise
AU - Chabbert-Buffet,
AU - Nathalie
AU - Kaaks, Rudolf
AU - Lukanova, Annekatrin
AU - Bergmann,
AU - Manuela M.
AU - Boeing, Heiner
AU - Trichopoulou, Antonia
AU - Oustoglou,
AU - Erifili
AU - Barbitsioti, Antonia
AU - Saieva, Calogero
AU - Tagliabue,
AU - Giovanna
AU - Galasso, Rocco
AU - Tumino, Rosario
AU - Sacerdote, Carlotta
AU - and Peeters, Petra H.
AU - Bueno-de-Mesquita, H. Bas
AU - Weiderpass,
AU - Elisabete
AU - Gram, Inger Torhild
AU - Sanchez, Soledad
AU - Duell, Eric
AU - J.
AU - Molina-Montes, Esther
AU - Arriola, Larraitz
AU - Chirlaque,
AU - Maria-Dolores
AU - Ardanaz, Eva
AU - Manjer, Jonas
AU - Lundin, Eva and
AU - Idahl, Annika
AU - Khaw, Kay-Tee
AU - Romaguera-Bosch, Dora
AU - Wark,
AU - Petra A.
AU - Norat, Teresa
AU - Romieu, Isabelle
JO - ANNALS OF EPIDEMIOLOGY
PY - 2013
VL - 23
TODO - 2
SP - 93-98
PB - EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
SN - 1047-2797
TODO - 10.1016/j.annepidem.2012.11.009
TODO - Endometrial neoplasms; Ethanol; Cohort studies; Western Europe
TODO - Purpose: Alcohol intake may adversely affect the concentrations of
endogenous sex hormones, and thus increase the risk of endometrial
cancer. However, epidemiologic studies have provided conflicting
results. Therefore, we investigated the association between alcohol
intake and endometrial cancer risk a large, multicenter, prospective
study.
Methods: From 1992 through 2010, 301,051 women in the European
Prospective Investigation into Cancer and Nutrition (EPIC) cohort were
followed for incident endometrial cancer (n = 1382). Baseline alcohol
consumption was assessed by country-specific, validated dietary
questionnaires. Information on past alcohol consumption was collected by
lifestyle questionnaires. Hazard ratios (HRs) and 95% confidence
intervals (CIs) were estimated from Cox proportional hazard models.
Results: The multivariable HRs (and 95% CIs) compared with light
drinkers (0.1-6 g/d) were 1.03(0.88-1.20) for 0 g of alcohol per day at
baseline, 1.01 (0.86-1.17) for 6.1-12 g/d, 1.03 (0.87-1.22) for 12.1-24
g/d, 1.07(0.87-1.38) for 241-36 g/d, and 0.85(0.61-1.18) for more than
36 g/d (p(trend) = 0.77). No association was observed among former
drinkers (OR, 1.28; 95% CI, 0.98-1.68 compared with light drinkers).
Null associations were also found between alcohol consumption at age 20
years, lifetime pattern of alcohol drinking, and baseline alcohol intake
from specific alcoholic beverages and endometrial cancer risk.
Conclusions: Our findings suggest no association between alcohol intake
and endometrial cancer risk. (c) 2013 Elsevier Inc. All rights reserved.
ER -