TY - JOUR
TI - Macronutrient Composition of the Diet and Prospective Weight Change in
Participants of the EPIC-PANACEA Study
AU - Vergnaud, Anne-Claire
AU - Norat, Teresa
AU - Mouw, Traci
AU - Romaguera,
AU - Dora
AU - May, Anne M.
AU - Bueno-de-Mesquita, H. Bas
AU - van der Daphne,
AU - A.
AU - Agudo, Antonio
AU - Wareham, Nicholas
AU - Khaw, Kay-Tee and
AU - Romieu, Isabelle
AU - Freisling, Heinz
AU - Slimani, Nadia
AU - Perquier,
AU - Florence
AU - Boutron-Ruault, Marie-Christine
AU - Clavel-Chapelon,
AU - Francoise
AU - Palli, Domenico
AU - Berrino, Franco
AU - Mattiello, Amalia
AU - and Tumino, Rosario
AU - Ricceri, Fulvio
AU - Rodriguez, Laudina and
AU - Molina-Montes, Esther
AU - Amiano, Pilar
AU - Barricarte, Aurelio and
AU - Chirlaque, Maria-Dolores
AU - Crowe, Francesca L.
AU - Orfanos, Philippos
AU - and Naska, Androniki
AU - Trichopoulou, Antonia
AU - Teucher, Birgit and
AU - Kaaks, Rudolf
AU - Boeing, Heiner
AU - Buijsse, Brian
AU - Johansson,
AU - Ingeged
AU - Hallmans, Goran
AU - Drake, Isabel
AU - Sonestedt, Emily and
AU - Jakobsen, Marianne Uhre
AU - Overvad, Kim
AU - Tjonneland, Anne and
AU - Halkjaer, Jytte
AU - Skeie, Guri
AU - Braaten, Tonje
AU - Lund, Eiliv and
AU - Riboli, Elio
AU - Peeters, Petra H. M.
JO - PLOS ONE
PY - 2013
VL - 8
TODO - 3
SP - null
PB - Public Library of Science
SN - null
TODO - 10.1371/journal.pone.0057300
TODO - null
TODO - Background: The effect of the macronutrient composition of the usual
diet on long term weight maintenance remains controversial.
Methods: 373,803 subjects aged 25-70 years were recruited in 10 European
countries (1992-2000) in the PANACEA project of the EPIC cohort. Diet
was assessed at baseline using country-specific validated questionnaires
and weight and height were measured at baseline and self-reported at
follow-up in most centers. The association between weight change after 5
years of follow-up and the iso-energetic replacement of 5% of energy
from one macronutrient by 5% of energy from another macronutrient was
assessed using multivariate linear mixed-models. The risk of becoming
overweight or obese after 5 years was investigated using multivariate
Poisson regressions stratified according to initial Body Mass Index.
Results: A higher proportion of energy from fat at the expense of
carbohydrates was not significantly associated with weight change after
5 years. However, a higher proportion of energy from protein at the
expense of fat was positively associated with weight gain. A higher
proportion of energy from protein at the expense of carbohydrates was
also positively associated with weight gain, especially when
carbohydrates were rich in fibre. The association between percentage of
energy from protein and weight change was slightly stronger in
overweight participants, former smokers, participants >= 60 years old,
participants underreporting their energy intake and participants with a
prudent dietary pattern. Compared to diets with no more than 14% of
energy from protein, diets with more than 22% of energy from protein
were associated with a 23-24% higher risk of becoming overweight or
obese in normal weight and overweight subjects at baseline.
Conclusion: Our results show that participants consuming an amount of
protein above the protein intake recommended by the American Diabetes
Association may experience a higher risk of becoming overweight or obese
during adult life.
ER -