TY - JOUR TI - Time Recall; Future Concept of Chronomodulating Chemotherapy for Cancer AU - Zarogoulidis, Paul AU - Darwiche, Kaid AU - Huang, Haidong AU - Spyratos, AU - Dionysis AU - Yarmus, Lonny AU - Li, Qiang AU - Kakolyris, Stylianos and AU - Syrigos, Konstantinos AU - Zarogoulidis, Konstantinos JO - Current Pharmaceutical Biotechnology PY - 2013 VL - 14 TODO - 6 SP - 632-642 PB - BENTHAM SCIENCE PUBL LTD SN - 1389-2010 TODO - 10.2174/13892010113146660229 TODO - Chronomodulation; Cancer; Chemotherapy; Circadian rhythm; Sleep disorders TODO - The human metabolism is regulated by our internal clock; the circadian rhythm (24h-25h). There are several factors included in the regulatory pathway such as; genes (PER1-3), (CRY1-2), TIM hormones (cortisol, catecholamines, melatonin and insulin) drugs, enzymes, sleep disorders and diseases. Each one contributes in a different degree and in order to enhance the therapeutic result; we should include these factors into clusters instead of targeting each factor one by one. Malignances deregulate gene-protein expression/production, enzyme production, and in addition they induce fatigue, insomnia, stress and sleep disorders. All these factors finally contribute in minimizing the efficiency of chemotherapy treatment and quality of life. In addition, the circadian rhythm disruption induces tumor genesis, stress, and down-regulates the defense and repair mechanisms of the human body. In the current mini review the underlying mechanism of the circadian rhythm is provided, along with the influence of sleep disturbances in cancer patient therapy. A proposal is presented to divide circadian rhythm and sleep disturbances into two major clusters with different management, however; with a common target to improve treatment efficiency and quality of life. Finally, a chrono-chemotherapy administration model is proposed in order to have less chemotherapy side effects. ER -