TY - JOUR
TI - Impaired glucose homeostasis in non-diabetic Greek hypertensives with
diabetes family history. Effect of the obesity status
AU - Vyssoulis, Gregory P.
AU - Liakos, Charalampos I.
AU - Karpanou, Eva A.
AU - and Triantafyllou, Athanasios I.
AU - Michaelides, Andreas P.
AU - Tzamou,
AU - Vanessa E.
AU - Markou, Maria I.
AU - Stefanadis, Christodoulos I.
JO - Journal of the American Society of Hypertension
PY - 2013
VL - 7
TODO - 4
SP - 294-304
PB - EXCERPTA MEDICA INC-ELSEVIER SCIENCE INC
SN - 1933-1711
TODO - 10.1016/j.jash.2013.02.007
TODO - Arterial hypertension; diabetes family history; impaired glucose
homeostasis; obesity; pre-diabetes; type 2 diabetes
TODO - Arterial hypertension (AH) and diabetes mellitus (DM) are established
cardiovascular risk factors. Impaired glucose homeostasis (IGH; impaired
fasting glucose or/and impaired glucose tolerance) or pre-diabetes,
obesity, and DM family history identify individuals at risk for type 2
DM in whom preventive interventions are necessary. The aim of this study
was to determine the glycemic profile in non-diabetic Greek adult
hypertensive men and women according to DM family history and the
obesity status. Diabetes family history, obesity markers (waist-to-hip
ratio, WHR; body mass index, BMI), glycemic parameters (fasting and
2-hour post-load plasma glucose, if necessary; glycated hemoglobin,
HbA(l)c; fasting insulin), insulin resistance indices (homeostasis model
assessment, HOMA; quantitative insulin sensitivity check index, QUICKI;
Bennett; McAuley), and IGH prevalence were determined in a large cohort
of 11,540 Greek hypertensives referred to our institutions. Positive DM
family history was associated with elevated fasting glucose (98.6 +/-
13.1 vs 96.5 +/- 12.3 mg/dL), HbA(l)c (5.58% +/- 0.49% vs 5.50% +/-
0.46%), fasting insulin (9.74 +/- 4.20 vs 9.21 +/- 3.63 mu U/mL) and
HOMA (2.43 +/- 1.19 vs 2.24 +/- 1.01) values, lower QUICKI (0.342 +/-
0.025 vs 0.345 +/- 0.023), Bennett (0.285 +/- 0.081 vs 0.292 +/- 0.078)
and McAuley (6.73 +/- 3.43 vs 6.95 +/- 3.44) values, and higher IGH
prevalence (45.3% vs 38.7%); P < .01 for all comparisons. The
difference in the prevalence of IGH according to DM family history was
significant (P < .01) in both genders and every WHR and BMI subgroup
(except for women with BMI <20 kg/m(2)). Non-diabetic hypertensives with
positive DM family history present with higher IGH prevalence and worse
glycemic indices levels compared with those with negative family
history, especially in the higher WHR/BMI subgroups. (c) 2013 American
Society of Hypertension. All rights reserved.
ER -