TY - JOUR
TI - Occupation and risk of lymphoid and myeloid leukaemia in the European
Prospective Investigation into Cancer and Nutrition (EPIC)
AU - Hosnijeh, Fatemeh Saberi
AU - Christopher, Yvette
AU - Peeters, Petra and
AU - Romieu, Isabelle
AU - Xun, Wei
AU - Riboli, Elio
AU - Raaschou-Nielsen, Ole
AU - and Tjonneland, Anne
AU - Becker, Nikolaus
AU - Nieters, Alexandra and
AU - Trichopoulou, Antonia
AU - Bamia, Christina
AU - Orfanos, Philip and
AU - Oddone, Enrico
AU - Lujan-Barroso, Leila
AU - Dorronsoro, Miren and
AU - Navarro, Carmen
AU - Barricarte, Aurelio
AU - Molina-Montes, Esther and
AU - Wareham, Nick
AU - Vineis, Paolo
AU - Vermeulen, Roel
JO - Annals of Occupational and Environmental Medicine
PY - 2013
VL - 70
TODO - 7
SP - 464-470
PB - BMJ Publishing Group
SN - 2052-4374
TODO - 10.1136/oemed-2012-101135
TODO - null
TODO - Objectives Established risk factors for leukaemia do not explain the
majority of leukaemia cases. Previous studies have suggested the
importance of occupation and related exposures in leukaemogenesis. We
evaluated possible associations between job title and selected hazardous
agents and leukaemia in the European Prospective Investigation into
Cancer and Nutrition.
Methods The mean follow-up time for 241 465 subjects was 11.20 years (SD
2.42 years). During the follow-up period, 477 incident cases of myeloid
and lymphoid leukaemia occurred. Data on 52 occupations considered a
priori to be at high risk of developing cancer were collected through
standardised questionnaires. Occupational exposures were estimated by
linking the reported occupations to a job exposure matrix. Cox
proportional hazard models were used to explore the association between
occupation and related exposures and risk of leukaemia.
Results The risk of lymphoid leukaemia significantly increased for
working in chemical laboratories (HR 8.35, 95% CI 1.58 to 44.24), while
the risk of myeloid leukaemia increased for working in the shoe or other
leather goods industry (HR 2.54, 95% CI 1.28 to 5.06).
Exposure-specific analyses showed a non-significant increased risk of
myeloid leukaemias for exposure to benzene (HR 1.15, 95% CI 0.75 to
1.40; HR=1.60, 95% CI 0.95 to 2.69 for the low and high exposure
categories, respectively). This association was present both for acute
and chronic myeloid leukaemia at high exposure levels. However, numbers
were too small to reach statistical significance.
Conclusions Our findings suggest a possible role of occupational
exposures in the development of both lymphoid and myeloid leukaemia.
Exposure to benzene seemed to be associated with both acute and chronic
myeloid leukaemia.
ER -