TY - JOUR
TI - Leptin at the Intersection of Neuroendocrinology and Metabolism: Current
Evidence and Therapeutic Perspectives
AU - Dalamaga, Maria
AU - Chou, Sharon H.
AU - Shields, Kelsey and
AU - Papageorgiou, Panagiotis
AU - Polyzos, Stergios A.
AU - Mantzoros,
AU - Christos S.
JO - Cell Metabolism
PY - 2013
VL - 18
TODO - 1
SP - 29-42
PB - Cell Press
SN - null
TODO - 10.1016/j.cmet.2013.05.010
TODO - null
TODO - Since its discovery as an adipocyte-secreted hormone, leptin has been
found to impact food intake, energy homeostasis, and metabolism through
its effects on the central nervous system and peripheral organs. Recent
research indicates that leptin may also be involved in cognition, immune
function, and bone metabolism. These findings place leptin at the
intersection of neuroendocrinology and metabolism, and possibly immune
function, and render it an appealing therapeutic target for several
niche areas of unmet clinical need. Current evidence regarding classic
and emerging roles of leptin as well as the pros and cons of its
potential clinical use are summarized herein.
ER -