TY - JOUR
TI - Prevalence of non classical congenital adrenal hyperplasia due to
21-hydroxylase deficiency in Greek women with acne: a hospital-based
cross-sectional study
AU - Trakakis, E.
AU - Papadavid, E.
AU - Dalamaga, M.
AU - Koumaki, D. and
AU - Stavrianeas, N.
AU - Rigopoulos, D.
AU - Creatsas, G.
AU - Kassanos, D.
JO - Journal of the European Academy of Dermatology and Venereology
PY - 2013
VL - 27
TODO - 11
SP - 1448-1451
PB - Wiley-Blackwell
SN - 0926-9959, 1468-3083
TODO - 10.1111/j.1468-3083.2012.04613.x
TODO - null
TODO - Aim To determine the prevalence and frequency of non classical
congenital adrenal hyperplasia (NC-CAH) due to 21-OHD at the time of
clinical presentation and at the peripubertal period in a substantial
sample of Greek women with acne and to investigate the correlation of
serum T, 17-OHP and DHEA-S with acne appearance at the time of clinical
presentation. Methods One hundred and twenty-three unselected women with
hyperandrogenemic symptoms were examined. After the ACTH stimulation
test, 6 (4.9%) women were diagnosed with NC-CAH due to 21-OHD. Results
There was not any statistical significant difference in the frequency of
peripubertal acne between NC-CAH group of patients (6.4%) and patients
with hyperandrogenemia of other aetiology (93%), mainly ovarian
(P=0.41). However, there was a statistical significant difference in the
prevalence of acne at the time of clinical examination between the two
groups (P=0.04). Acne was present in 83.3% of women with NC-CAH vs.
41.02% of women in the hyperandrogenic group without NC-CAH. A
statistically significant decrease of acne from the peripubertal time to
the time of clinical examination in the group of women with
hyperandrogenemia of other aetiology (-21.37%) was observed compared to
women with NC-CAH (P<0.001). Conclusion We have shown that acne persists
from peripubertal period to adult life in NC-CAH women whereas it tends
to diminish in women with hyperandrogenemia of other aetiology. Acne is
a prominent finding in women with NC-CAH. Serum concentrations of 17-OHP
after ACTH stimulation (17-OHP6O) should be investigated in women with
persistent acne in adult life.
ER -