TY - JOUR
TI - Lifestyle, dietary factors, and antibody levels to oral bacteria in
cancer-free participants of a European cohort study
AU - Michaud, Dominique S.
AU - Izard, Jacques
AU - Rubin, Zachary and
AU - Johansson, Ingegerd
AU - Weiderpass, Elisabete
AU - Tjonneland, Anne and
AU - Olsen, Anja
AU - Overvad, Kim
AU - Boutron-Ruault, Marie Christine and
AU - Clavel-Chapelon, Francoise
AU - Dossus, Laure
AU - Kaaks, Rudolf and
AU - Katzke, Verena A.
AU - Boeing, Heiner
AU - Foerster, Jana and
AU - Trichopoulou, Antonia
AU - Naska, Androniki
AU - Ziara, Giana
AU - Vineis,
AU - Paolo
AU - Grioni, Sara
AU - Palli, Domenico
AU - Tumino, Rosario and
AU - Mattiello, Amalia
AU - Peeters, Petra H. M.
AU - Siersema, Peter D. and
AU - Barricarte, Aurelio
AU - Huerta, Jose-Maria
AU - Molina-Montes, Esther and
AU - Dorronsoro, Miren
AU - Ramon Quiros, J.
AU - Duell, Eric J.
AU - Ohlsson,
AU - Bodil
AU - Jeppsson, Bengt
AU - Johansson, Anders
AU - Lif, Pernilla and
AU - Khaw, Kay-Tee
AU - Wareham, Nick
AU - Travis, Ruth C.
AU - Key, Tim J. and
AU - Freisling, Heinz
AU - Duarte-Salles, Talita
AU - Stepien, Magdalena and
AU - Riboli, Elio
AU - Bueno-de-Mesquita, H. Bas
JO - Cancer Causes and Control
PY - 2013
VL - 24
TODO - 11
SP - 1901-1909
PB - Springer-Verlag
SN - 0957-5243, 1573-7225
TODO - 10.1007/s10552-013-0265-2
TODO - Antibodies to oral bacteria; Smoking; Lifestyle factors
TODO - Increasing evidence suggests that oral microbiota play a pivotal role in
chronic diseases, in addition to the well-established role in
periodontal disease. Moreover, recent studies suggest that oral bacteria
may also be involved in carcinogenesis; periodontal disease has been
linked to several cancers. In this study, we examined whether lifestyle
factors have an impact on antibody levels to oral bacteria.
Data on demographic characteristics, lifestyle factors, and medical
conditions were obtained at the time of blood sample collection. For the
current analysis, we measured antibody levels to 25 oral bacteria in 395
cancer-free individuals using an immunoblot array. Combined total
immunoglobin G (IgG) levels were obtained by summing concentrations for
all oral bacteria measured.
IgG antibody levels were substantially lower among current and former
smokers (1,697 and 1,677 ng/mL, respectively) than never smokers (1,960
ng/mL; p trend = 0.01), but did not vary by other factors, including
body mass index, diabetes, physical activity, or by dietary factors,
after adjusting for age, sex, education, country, and smoking status.
The highest levels of total IgG were found among individuals with low
education (2,419 ng/mL).
Our findings on smoking are consistent with previous studies and support
the notion that smokers have a compromised humoral immune response.
Moreover, other major factors known to be associated with inflammatory
markers, including obesity, were not associated with antibody levels to
a large number of oral bacteria.
ER -