TY - JOUR
TI - Weight change later in life and colon and rectal cancer risk in
participants in the EPIC-PANACEA study
AU - Bisschop, Charlotte N. Steins
AU - van Gils, Carla H.
AU - Emaus, Marleen
AU - J.
AU - Bueno-de-Mesquita, H. Bas
AU - Monninkhof, Evelyn M.
AU - Boeing,
AU - Heiner
AU - Aleksandrova, Krasmira
AU - Jenab, Mazda
AU - Norat, Teresa and
AU - Riboli, Elio
AU - Boutron-Ruault, Marie-Christine
AU - Fagherazzi, Guy and
AU - Racine, Antoine
AU - Palli, Domenico
AU - Krogh, Vittorio
AU - Tumino,
AU - Rosario
AU - Naccarati, Alessio
AU - Mattiello, Amalia
AU - Vicente
AU - Argueeles, Marcial
AU - Jose Sanchez, Maria
AU - Jose Tormo, Maria and
AU - Ardanaz, Eva
AU - Dorronsoro, Miren
AU - Bonet, Catalina
AU - Khaw, Kay-Tee
AU - and Key, Tim
AU - Trichopoulou, Antonia
AU - Orfanos, Philippos
AU - Naska,
AU - Androniki
AU - Kaaks, Rudolph R.
AU - Lukanova, Annekatrin
AU - Pischon,
AU - Tobias
AU - Ljuslinder, Ingrid
AU - Jirstrom, Karin
AU - Ohlsson, Bodil and
AU - Overvad, Kim
AU - Berentzen, Tina Landsvig
AU - Halkjaer, Jytte and
AU - Tjonneland, Anne
AU - Weiderpass, Elisabete
AU - Skeie, Guri
AU - Braaten,
AU - Tonje
AU - Siersema, Peter D.
AU - Freisling, Heinz
AU - Ferrari, Pietro
AU - and Peeters, Petra H. M.
AU - May, Anne M.
JO - AMERICAN JOURNAL OF CLINICAL NUTRITION
PY - 2014
VL - 99
TODO - 1
SP - 139-147
PB - Oxford University Press
SN - 0002-9165
TODO - 10.3945/ajcn.113.066530
TODO - null
TODO - Background: A moderate association exists between body mass index (BMI)
and colorectal cancer. Less is known about the effect of weight change.
Objective: We investigated the relation between BMI and weight change
and subsequent colon and rectal cancer risk.
Design: This was studied among 328,781 participants in the prospective
European Prospective Investigation into Cancer Physical Activity,
Nutrition, Alcohol, Cessation of Smoking, Eating study (mean age: 50 y).
Body weight was assessed at recruitment and on average 5 y later.
Self-reported weight change (kg/y) was categorized in sex-specific
quintiles, with quintiles 2 and 3 combined as the reference category
(men: -0.6 to 0.3 kg/y; women: -0.4 to 0.4 kg/y). In the subsequent
years, participants were followed for the occurrence of colon and rectal
cancer (median period: 6.8 y). Multivariable Cox proportional hazards
regression analyses were used to study the association.
Results: A total of 1261 incident colon cancer and 747 rectal cancer
cases were identified. ME at recruitment was statistically significantly
associated with colon cancer risk in men (HR: 1.04; 95% CI: 1.02,
1.07). Moderate weight gain (quintile 4) in men increased risk further
(HR: 1.32; 95% CI: 1.04, 1.68), but this relation did not show a clear
trend. In women, BMI or weight gain was not related to subsequent risk
of colon cancer. No statistically significant associations for weight
loss and colon cancer or for BMI and weight changes and rectal cancer
were found.
Conclusions: BMI attained at adulthood was associated with colon cancer
risk. Subsequent weight gain or loss was not related to colon or rectal
cancer risk in men or women.
ER -