TY - JOUR
TI - Plasma Alkylresorcinols, Biomarkers of Whole-Grain Wheat and Rye Intake,
and Incidence of Colorectal Cancer
AU - Kyro, Cecilie
AU - Olsen, Anja
AU - Landberg, Rikard
AU - Skeie, Guri and
AU - Loft, Steffen
AU - Aman, Per
AU - Leenders, Max
AU - Dik, Vincent K. and
AU - Siersema, Peter D.
AU - Pischon, Tobias
AU - Christensen, Jane and
AU - Overvad, Kim
AU - Boutron-Ruault, Marie-Christine
AU - Fagherazzi, Guy and
AU - Cottet, Vanessa
AU - Kuehn, Tilman
AU - Chang-Claude, Jenny
AU - Boeing,
AU - Heiner
AU - Trichopoulou, Antonia
AU - Bamia, Christina
AU - Trichopoulos,
AU - Dimitrios
AU - Palli, Domenico
AU - Krogh, Vittorio
AU - Tumino, Rosario
AU - and Vineis, Paolo
AU - Panico, Salvatore
AU - Peeters, Petra H. and
AU - Weiderpass, Elisabete
AU - Bakken, Toril
AU - Asli, Lene Angell and
AU - Argueelles, Marcial
AU - Jakszyn, Paula
AU - Sanchez, Maria-Jose and
AU - Amiano, Pilar
AU - Huerta, Jose Maria
AU - Barricarte, Aurelio and
AU - Ljuslinder, Ingrid
AU - Palmqvist, Richard
AU - Khaw, Kay-Tee
AU - Wareham,
AU - Nick
AU - Key, Timothy J.
AU - Travis, Ruth C.
AU - Ferrari, Pietro and
AU - Freisling, Heinz
AU - Jenab, Mazda
AU - Gunter, Marc J.
AU - Murphy, Neil
AU - and Riboli, Eilo
AU - Tjonneland, Anne
AU - Bueno-de-Mesquita, H. B(as)
JO - JNCI Journal of the National Cancer Institute
PY - 2014
VL - 106
TODO - 1
SP - null
PB - OXFORD UNIV PRESS INC
SN - 0027-8874, 1460-2105
TODO - 10.1093/jnci/djt352
TODO - null
TODO - Background Few studies have investigated the association between
whole-grain intake and colorectal cancer. Because whole-grain intake
estimation might be prone to measurement errors, more objective measures
(eg, biomarkers) could assist in investigating such associations.
Methods The association between alkylresorcinols, biomarkers of
whole-grain rye and wheat intake, and colorectal cancer incidence were
investigated using prediagnostic plasma samples from colorectal cancer
case patients and matched control subjects nested within the European
Prospective Investigation into Cancer and Nutrition. We included 1372
incident colorectal cancer case patients and 1372 individual matched
control subjects and calculated the incidence rate ratios (IRRs) for
overall and anatomical subsites of colorectal cancer using conditional
logistic regression adjusted for potential confounders. Regional
differences (Scandinavia, the Mediterranean, Central Europe) were also
explored.
Results High plasma total alkylresorcinol concentration was associated
with lower incidence of distal colon cancer; the adjusted incidence rate
ratio of distal colon cancer for the highest vs lowest quartile of
plasma total alkylresorcinols was 0.48 (95% confidence interval [CI]
= 0.28 to 0.83). An inverse association between plasma total
alkylresorcinol concentrations and colon cancer was found for
Scandinavian participants (IRR per doubling = 0.83; 95% CI = 0.70 to
0.98). However, plasma total alkylresorcinol concentrations were not
associated with overall colorectal cancer, proximal colon cancer, or
rectal cancer. Plasma alkylresorcinols concentrations were associated
with colon and distal colon cancer only in Central Europe and
Scandinavia (ie, areas where alkylresorcinol levels were higher).
Conclusions High concentrations of plasma alkylresorcinols were
associated with a lower incidence of distal colon cancer but not with
overall colorectal cancer, proximal colon cancer, and rectal cancer.
ER -