TY - JOUR
TI - Dietary intake of acrylamide and esophageal cancer risk in the European
Prospective Investigation into Cancer and Nutrition cohort
AU - Lujan-Barroso, Leila
AU - Alberto Gonzalez, Carlos
AU - Slimani, Nadia and
AU - Obon-Santacana, Mireia
AU - Ferrari, Pietro
AU - Freisling, Heinz and
AU - Overvad, Kim
AU - Clavel-Chapelon, Francoise
AU - Boutron-Ruault,
AU - Marie-Christine
AU - Racine, Antoine
AU - Katzke, Verena
AU - Kuehn, Tilman
AU - and Tjonneland, Anne
AU - Olsen, Anja
AU - Ramon Quiros, J. and
AU - Sanchez-Cantalejo, Emilio
AU - Amiano, Pilar
AU - Navarro, Carmen and
AU - Barricarte, Aurelio
AU - Khaw, Kay-Tee
AU - Wareham, Nick
AU - Travis, Ruth
AU - C.
AU - Trichopoulou, Antonia
AU - Bamia, Christina
AU - Benetou, Vassiliki
AU - and Saieva, Calogero
AU - Grioni, Sara
AU - Tumino, Rosario
AU - Vineis,
AU - Paolo
AU - Mattiello, Amalia
AU - Bueno-de-Mesquita, H. Bas
AU - Siersema,
AU - Peter D.
AU - Numans, Mattijs E.
AU - Peeters, Petra H.
AU - Ericson,
AU - Ulrika
AU - Wirfaelt, Elisabet
AU - Sund, Malin
AU - Johansson, Mattias and
AU - Weiderpass, Elisabete
AU - Skeie, Guri
AU - Riboli, Elio
AU - Boeing,
AU - Heiner
AU - Duell, Eric J.
JO - Cancer Causes and Control
PY - 2014
VL - 25
TODO - 5
SP - 639-646
PB - Springer-Verlag
SN - 0957-5243, 1573-7225
TODO - 10.1007/s10552-014-0359-5
TODO - Esophageal cancer; Esophageal squamous cell carcinoma; Esophageal
adenocarcinoma; Acrylamide intake; Cohort; Nutrition
TODO - The relation between dietary acrylamide intake and esophageal cancer
(EC) risk, including esophageal adenocarcinoma (EAC) and esophageal
squamous cell carcinoma (ESCC), has not been consistent. We evaluated
the association between dietary acrylamide intake and EAC, ESCC, and
overall EC in the European Prospective Investigation into Cancer and
Nutrition (EPIC) cohort.
Multivariate Cox proportional hazards models were used to estimate the
HR and 95 % confidence interval (95 % CI). Since nonlinear relations
were observed, HRs were displayed for quartiles of acrylamide intake in
mu g per day.
After a mean follow-up of 11 years, 341 EC were identified, 142 of which
were EAC, 176 ESCC, and 23 other histological types or not specified. An
increase in EC risk was observed in the second and third quartiles
(HRQ2vsQ1 1.75, 95 % CI 1.12-2.74; HRQ3vsQ1 1.66, 95 % CI 1.05-2.61),
but not in the fourth quartile, and there was no evidence for a linear
dose-response trend. HRs were similarly elevated but not statistically
significant when ESCC and EAC were analyzed separately, due to the small
number of cases observed. No associations were observed when quartiles
were based on energy-adjusted acrylamide intake.
In the EPIC cohort, an association between estimated dietary acrylamide
intake and an increased risk of developing EC was observed in the middle
quartiles but not in the highest quartile; however, results from other
larger cohorts or consortia, and results from biomarker studies, might
add to the evidence provided by this analysis, suggesting that
acrylamide is not an important risk factor for EC.
ER -