TY - JOUR
TI - Genome-wide interaction study of smoking and bladder cancer risk
AU - Figueroa, Jonine D.
AU - Han, Summer S.
AU - Garcia-Closas, Montserrat and
AU - Baris, Dalsu
AU - Jacobs, Eric J.
AU - Kogevinas, Manolis
AU - Schwenn,
AU - Molly
AU - Malats, Nuria
AU - Johnson, Alison
AU - Purdue, Mark P. and
AU - Caporaso, Neil
AU - Landi, Maria Teresa
AU - Prokunina-Olsson, Ludmila and
AU - Wang, Zhaoming
AU - Hutchinson, Amy
AU - Burdette, Laurie
AU - Wheeler,
AU - William
AU - Vineis, Paolo
AU - Siddiq, Afshan
AU - Cortessis, Victoria K.
AU - and Kooperberg, Charles
AU - Cussenot, Olivier
AU - Benhamou, Simone and
AU - Prescott, Jennifer
AU - Porru, Stefano
AU - Bueno-de-Mesquita, H. Bas and
AU - Trichopoulos, Dimitrios
AU - Ljungberg, Boerje
AU - Clavel-Chapelon,
AU - Franoise
AU - Weiderpass, Elisabete
AU - Krogh, Vittorio
AU - Dorronsoro,
AU - Miren
AU - Travis, Ruth
AU - Tjonneland, Anne
AU - Brenan, Paul and
AU - Chang-Claude, Jenny
AU - Riboli, Elio
AU - Conti, David and
AU - Gago-Dominguez, Manuela
AU - Stern, Mariana C.
AU - Pike, Malcolm C. and
AU - Van den Berg, David
AU - Yuan, Jian-Min
AU - Hohensee, Chancellor and
AU - Rodabough, Rebecca
AU - Cancel-Tassin, Geraldine
AU - Roupret, Morgan and
AU - Comperat, Eva
AU - Chen, Constance
AU - De Vivo, Immaculata and
AU - Giovannucci, Edward
AU - Hunter, David J.
AU - Kraft, Peter
AU - Lindstrom,
AU - Sara
AU - Carta, Angela
AU - Pavanello, Sofia
AU - Arici, Cecilia and
AU - Mastrangelo, Giuseppe
AU - Karagas, Margaret R.
AU - Schned, Alan and
AU - Armenti, Karla R.
AU - Hosain, G. M. Monawar
AU - Haiman, Chris A. and
AU - Fraumeni, Jr., Joseph F.
AU - Chanock, Stephen J.
AU - Chatterjee,
AU - Nilanjan
AU - Rothman, Nathaniel
AU - Silverman, Debra T.
JO - Journal of Carcinogenesis
PY - 2014
VL - 35
TODO - 8
SP - 1737-1744
PB - Oxford University Press
SN - 1477-3163
TODO - 10.1093/carcin/bgu064
TODO - null
TODO - Bladder cancer is a complex disease with known environmental and genetic
risk factors. We performed a genome-wide interaction study (GWAS) of
smoking and bladder cancer risk based on primary scan data from 3002
cases and 4411 controls from the National Cancer Institute Bladder
Cancer GWAS. Alternative methods were used to evaluate both additive and
multiplicative interactions between individual single nucleotide
polymorphisms (SNPs) and smoking exposure. SNPs with interaction P
values < 5 x 10(-5) were evaluated further in an independent dataset of
2422 bladder cancer cases and 5751 controls. We identified 10 SNPs that
showed association in a consistent manner with the initial dataset and
in the combined dataset, providing evidence of interaction with tobacco
use. Further, two of these novel SNPs showed strong evidence of
association with bladder cancer in tobacco use subgroups that approached
genome-wide significance. Specifically, rs1711973 (FOXF2) on 6p25.3 was
a susceptibility SNP for never smokers [combined odds ratio (OR) =
1.34, 95% confidence interval (CI) = 1.20-1.50, P value = 5.18 x
10(-7)]; and rs12216499 (RSPH3-TAGAP-EZR) on 6q25.3 was a susceptibility
SNP for ever smokers (combined OR = 0.75, 95% CI = 0.67-0.84, P value =
6.35 x 10-7). In our analysis of smoking and bladder cancer, the tests
for multiplicative interaction seemed to more commonly identify
susceptibility loci with associations in never smokers, whereas the
additive interaction analysis identified more loci with associations
among smokers-including the known smoking and NAT2 acetylation
interaction. Our findings provide additional evidence of
gene-environment interactions for tobacco and bladder cancer.
ER -