TY - JOUR
TI - Epigenetic programming of monocyte-to-macrophage differentiation and
trained innate immunity
AU - Saeed, Sadia
AU - Quintin, Jessica
AU - Kerstens, Hindrik H. D.
AU - Rao,
AU - Nagesha A.
AU - Aghajanirefah, Ali
AU - Matarese, Filomena
AU - Cheng,
AU - Shih-Chin
AU - Ratter, Jacqueline
AU - Berentsen, Kim
AU - van der Ent,
AU - Martijn A.
AU - Sharifi, Nilofar
AU - Janssen-Megens, Eva M.
AU - Ter
AU - Huurne, Menno
AU - Mandoli, Amit
AU - van Schaik, Tom
AU - Ng, Aylwin and
AU - Burden, Frances
AU - Downes, Kate
AU - Frontini, Mattia
AU - Kumar, Vinod
AU - and Giamarellos-Bourboulis, Evangelos J.
AU - Ouwehand, Willem H.
AU - van
AU - der Meer, Jos W. M.
AU - Joosten, Leo A. B.
AU - Wijmenga, Cisca and
AU - Martens, Joost H. A.
AU - Xavier, Ramnik J.
AU - Logie, Colin
AU - Netea,
AU - Mihai G.
AU - Stunnenberg, Hendrik G.
JO - SCIENCE CHINA Information Sciences
PY - 2014
VL - 345
TODO - 6204
SP - 1578+
PB - AMER ASSOC ADVANCEMENT SCIENCE
SN - null
TODO - 10.1126/science.1251086
TODO - null
TODO - Monocyte differentiation into macrophages represents a cornerstone
process for host defense. Concomitantly, immunological imprinting of
either tolerance or trained immunity determines the functional fate of
macrophages and susceptibility to secondary infections. We characterized
the transcriptomes and epigenomes in four primary cell types: monocytes
and in vitro-differentiated naive, tolerized, and trained macrophages.
Inflammatory and metabolic pathways were modulated in macrophages,
including decreased inflammasome activation, and we identified pathways
functionally implicated in trained immunity. beta-glucan training
elicits an exclusive epigenetic signature, revealing a complex network
of enhancers and promoters. Analysis of transcription factor motifs in
deoxyribonuclease I hypersensitive sites at cell-type-specific
epigenetic loci unveiled differentiation and treatment-specific
repertoires. Altogether, we provide a resource to understand the
epigenetic changes that underlie innate immunity in humans.
ER -