TY - JOUR
TI - Prediagnostic Circulating Vitamin D Levels and Risk of Hepatocellular
Carcinoma in European Populations: A Nested Case-Control Study
AU - Fedirko, Veronika
AU - Duarte-Salles, Talita
AU - Bamia, Christina and
AU - Trichopoulou, Antonia
AU - Aleksandrova, Krasimira
AU - Trichopoulos,
AU - Dimitrios
AU - Trepo, Elisabeth
AU - Tjonneland, Anne
AU - Olsen, Anja and
AU - Overvad, Kim
AU - Boutron-Ruault, Marie-Christine
AU - Clavel-Chapelon,
AU - Francoise
AU - Kvaskoff, Marina
AU - Kuehn, Tilman
AU - Lukanova, Annie and
AU - Boeing, Heiner
AU - Buijsse, Brian
AU - Klinaki, Eleni
AU - Tsimakidi,
AU - Chrysanthi
AU - Naccarati, Alessio
AU - Tagliabue, Giovanna
AU - Panico,
AU - Salvatore
AU - Tumino, Rosario
AU - Palli, Domenico
AU - Bueno-de-Mesquita,
AU - H. Bas
AU - Siersema, Peter D.
AU - Peters, Petra H.
AU - Lund, Eiliv and
AU - Brustad, Magritt
AU - Olsen, Karina Standahl
AU - Weiderpass, Elisabete
AU - and Zamora-Ros, Raul
AU - Sanchez, Maria-Jose
AU - Ardanaz, Eva and
AU - Amiano, Pilar
AU - Navarro, Carmen
AU - Ramon Quiros, J.
AU - Werner,
AU - Marten
AU - Sund, Malin
AU - Lindkvist, Bjorn
AU - Malm, Johan
AU - Travis,
AU - Ruth C.
AU - Khaw, Kay-Tee
AU - Stepien, Magdalena
AU - Scalbert, Augustin
AU - and Romieu, Isabelle
AU - Lagiou, Pagona
AU - Riboli, Elio
AU - Jenab,
AU - Mazda
JO - Gastroenterologie a Hepatologie
PY - 2014
VL - 60
TODO - 4
SP - 1222-1230
PB - Wiley
SN - null
TODO - 10.1002/hep.27079
TODO - null
TODO - The association between vitamin D status and hepatocellular carcinoma
(HCC) has not been well investigated, despite experimental evidence
supporting an important role of vitamin D in liver pathophysiology. Our
objective was to investigate the association between prediagnostic
circulating 25-hydroxyvitamin D [25(OH)D] serum levels and the risk of
HCC in a prospective, nested case-control study among 520,000
participants in the European Prospective Investigation into Cancer and
Nutrition (EPIC) cohort. Each case (n=138) diagnosed between 1992 and
2010 was matched to one control by age, sex, study center, date and time
of blood collection, and fasting status. Serum baseline levels of
25(OH)D were measured by liquid chromatography/tandem mass spectrometry.
Multivariable incident rate ratios (IRRs) of HCC associated with
continuous (per 10 nmol/L) or categorical levels (tertiles or a
priori-defined categories) of prediagnostic 25(OH)D were calculated
using conditional logistic regression. Higher 25(OH)D levels were
associated with a 49% reduction in the risk of HCC (highest versus
lowest tertile: multivariable IRR=0.51, 95% confidence interval [CI],
0.26 to 0.99; P-trend=0.04; per 10 nmol/L increase: IRR=0.80, 95% CI,
0.68-0.94). The finding did not vary substantially by time from
enrolment to diagnosis, and did not change after adjustment for
biomarkers of preexisting liver damage, nor chronic infection with
hepatitis B or C viruses. The findings were not modified by body size or
smoking status. Conclusion: In this prospective study on western
European populations, serum levels of 25(OH)D were inversely associated
with the risk of HCC. Given the rising incidence of this cancer in
low-risk developed countries and the strong public health interest
surrounding the potentially cancer-protective roles of vitamin D,
additional studies in different populations are required. (Hepatology
2014;60:1222-1230)
ER -