TY - JOUR
TI - Prediagnostic immunoglobulin E levels and risk of chronic lymphocytic
leukemia, other lymphomas and multiple myeloma-results of the European
Prospective Investigation into Cancer and Nutrition
AU - Nieters, Alexandra
AU - Luczynska, Anna
AU - Becker, Susen
AU - Becker,
AU - Nikolaus
AU - Vermeulen, Roel
AU - Overvad, Kim
AU - Aleksandrova,
AU - Krasimira
AU - Boeing, Heiner
AU - Lagiou, Pagona
AU - Trichopoulos,
AU - Dimitrios
AU - Trichopoulou, Antonia
AU - Krogh, Vittorio
AU - Masala,
AU - Giovanna
AU - Panico, Salvatore
AU - Tumino, Rosario
AU - Sacerdote,
AU - Carlotta
AU - Bueno-de-Mesquita, Bas
AU - Jeurnink, Suzanne M. and
AU - Weiderpass, Elisabete
AU - Ardanaz, Eva
AU - Chirlaque, Maria-Dolores and
AU - Sanchez, Maraia-Jose
AU - Sanchez, Soledad
AU - Borgquist, Signe
AU - Butt,
AU - Salma
AU - Melin, Beatrice
AU - Spaeth, Florentin
AU - Rinaldi, Sabina and
AU - Brennan, Paul
AU - Kelly, Rachel S.
AU - Riboli, Elio
AU - Vineis, Paolo
AU - and Kaaks, Rudolf
JO - Journal of Carcinogenesis
PY - 2014
VL - 35
TODO - 12
SP - 2716-2722
PB - Oxford University Press
SN - 1477-3163
TODO - 10.1093/carcin/bgu188
TODO - null
TODO - Previous epidemiological studies suggest an inverse association between
allergies, marked by elevated immunoglobulin (Ig) E levels, and
non-Hodgkin lymphoma (NHL) risk. The evidence, however, is inconsistent
and prospective data are sparse. We examined the association between
prediagnostic total (low: < 20; intermediate: 20-100; high > 100 kU/l)
and specific IgE (negative: < 0.35; positive >= 0.35 kU/I)
concentrations against inhalant antigens and lymphoma risk in a study
nested within the European Prospective Investigation into Cancer and
Nutrition cohort. A total of 1021 incident cases and matched controls of
NHL, multiple myeloma (MM) and Hodgkin lymphoma with a mean follow-up
time of 7 years were investigated. Multivariate-adjusted odds ratios
(ORs) with 95% confidence intervals (CI) were calculated by conditional
logistic regression. Specific IgE was not associated with the risk of
MM, B-cell NHL and B-cell NHL subtypes. In contrast, total IgE levels
were inversely associated with the risk of MM [high level: OR = 0.40
(95% CI = 0.21-0.79)] and B-cell NHL [intermediate level: OR = 0.68
(95% CI = 0.53-0.88); high level: OR = 0.62 (95% CI = 0.44-0.86)],
largely on the basis of a strong inverse association with chronic
lymphocytic leukemia [CLL; intermediate level: OR = 0.49 (95% CI =
0.30-0.80); high level: OR = 0.13 (95% CI = 0.05-0.35)] risk. The
inverse relationship for CLL remained significant for those diagnosed 5
years after baseline. The findings of this large prospective study
demonstrated significantly lower prediagnostic total IgE levels among
CLL and MM cases compared with matched controls. This corresponds to the
clinical immunodeficiency state often observed in CLL patients prior to
diagnosis. No support for an inverse association between prediagnostic
levels of specific IgE and NHL risk was found.
ER -