TY - JOUR
TI - Homocysteine, Cortisol, Diabetes Mellitus, and Psychopathology
AU - Kontoangelos, K.
AU - Papageorgiou, C. C.
AU - Raptis, A. E.
AU - Tsiotra,
AU - P.
AU - Lambadiari, V.
AU - Papadimitriou, G. N.
AU - Rabavilas, A. D. and
AU - Dimitriadis, G.
AU - Raptis, S. A.
JO - Journal of Diabetes Research
PY - 2015
VL - 2015
TODO - null
SP - null
PB - HINDAWI LTD
SN - 2314-6745, 2314-6753
TODO - 10.1155/2015/354923
TODO - null
TODO - Objective. This study investigates the association of homocysteine and
cortisol with psychological factors in type 2 diabetic patients. Method.
Homocysteine, cortisol, and psychological variables were analyzed from
131 diabetic patients. Psychological factors were assessed with the
Eysenck Personality Questionnaire (EPQ), Hostility and Direction of
Hostility Questionnaire (HDHQ), the Symptom Checklist 90-R (SCL 90-R),
the Zung Self-Rating Depression Scale (ZDRS), and the Maudsley O-C
Inventory Questionnaire (MOCI). Blood samples were taken by measuring
homocysteine and cortisol in both subgroups during the initial phase of
the study (T0). One year later (T1), the uncontrolled diabetic patients
were reevaluated with the use of the same psychometric instruments and
with an identical blood analysis. Results. The relation of psychoticism
and homocysteine is positive among controlled diabetic patients (P value
= 0.006 < 0.05) and negative among uncontrolled ones (P value = 0.137).
Higher values of cortisol correspond to lower scores on extraversion
subscale (r(p) = -0.223, P value = 0.010). Controlled diabetic patients
showed a statistically significant negative relationship between
homocysteine and the act-out hostility subscale (r(sp) = -0.247, P =
0.023). There is a statistically significant relationship between
homocysteine and somatization (r(sp) = -0.220, P = 0.043). Conclusions.
These findings support the notion that homocysteine and cortisol are
related to trait and state psychological factors in patients with
diabetes mellitus type 2.
ER -