TY - JOUR
TI - Insulin-like growth factor I and risk of epithelial invasive ovarian
cancer by tumour characteristics: results from the EPIC cohort
AU - Ose, J.
AU - Fortner, R. T.
AU - Schock, H.
AU - Peeters, P. H. and
AU - Onland-Moret, N. C.
AU - Bueno-de-Mesquita, H. B.
AU - Weiderpass, E. and
AU - Gram, I. T.
AU - Overvad, K.
AU - Tjonneland, A.
AU - Dossus, L. and
AU - Fournier, A.
AU - Baglietto, L.
AU - Trichopoulou, A.
AU - Benetou, V. and
AU - Trichopoulos, D.
AU - Boeing, H.
AU - Masala, G.
AU - Krogh, V. and
AU - Matiello, A.
AU - Tumino, R.
AU - Popovic, M.
AU - Obon-Santacana, M. and
AU - Larranaga, N.
AU - Ardanaz, E.
AU - Sanchez, M-J
AU - Menendez, V. and
AU - Chirlaque, M-D
AU - Travis, R. C.
AU - Khaw, K-T
AU - Braendstedt, J. and
AU - Idahl, A.
AU - Lundin, E.
AU - Rinaldi, S.
AU - Kuhn, E.
AU - Romieu, I. and
AU - Gunter, M. J.
AU - Merritt, M. A.
AU - Riboli, E.
AU - Kaaks, R.
JO - British Journal of Cancer
PY - 2015
VL - 112
TODO - 1
SP - 162-166
PB - Nature Publishing Group
SN - 0007-0920, 1532-1827
TODO - 10.1038/bjc.2014.566
TODO - IGF-I; ovarian cancer; histological subtypes; carcinogenesis; type
I/type II; dualistic pathway
TODO - Background: Prospective studies on insulin-like growth factor I (IGF-I)
and epithelial ovarian cancer (EOC) risk are inconclusive. Data suggest
risk associations vary by tumour characteristics.
Methods: We conducted a nested case-control study in the European
Prospective Investigation into Cancer and Nutrition (EPIC) to evaluate
IGF-I concentrations and EOC risk by tumour characteristics (n = 565
cases). Multivariable conditional logistic regression models were used
to estimate associations.
Results: We observed no association between IGF-I and EOC overall or by
tumour characteristics.
Conclusions: In the largest prospective study to date was no association
between IGF-I and EOC risk. Pre-diagnostic serum IGF-I concentrations
may not influence EOC risk.
ER -