TY - JOUR
TI - Plasma Elaidic Acid Level as Biomarker of Industrial Trans Fatty Acids
and Risk of Weight Change: Report from the EPIC Study
AU - Chajes, Veronique
AU - Biessy, Carine
AU - Ferrari, Pietro
AU - Romieu,
AU - Isabelle
AU - Freisling, Heinz
AU - Huybrechts, Inge
AU - Scalbert,
AU - Augustin
AU - de Mesquita, Bas Bueno
AU - Romaguera, Dora
AU - Gunter, Marc
AU - J.
AU - Vineis, Paolo
AU - Hansen, Camilla Plambeck
AU - Jakobsen, Marianne
AU - Uhre
AU - Clavel-Chapelon, Francoise
AU - Fagherazzi, Guy and
AU - Boutron-Ruault, Marie-Christine
AU - Katzke, Verana
AU - Neamat-Allah,
AU - Jasmine
AU - Boeing, Heiner
AU - Bachlechner, Ursula
AU - Trichopoulou,
AU - Antonia
AU - Naska, Androniki
AU - Orfanos, Philippos
AU - Pala, Valeria
AU - and Masala, Giovanna
AU - Mattiello, Amalia
AU - Skeie, Guri and
AU - Weiderpass, Elisabete
AU - Agudo, Antonio
AU - Maria Huerta, Jose and
AU - Ardanaz, Eva
AU - Jose Sanchez, Maria
AU - Dorronsoro, Miren
AU - Ramon
AU - Quiros, Jose
AU - Johansson, Ingegerd
AU - Winkvist, Anna
AU - Sonested,
AU - Emily
AU - Key, Tim
AU - Khaw, Kay-Tee
AU - Wareham, Nicolas J. and
AU - Peeters, Petra H. M.
AU - Slimani, Nadia
JO - PLOS ONE
PY - 2015
VL - 10
TODO - 2
SP - null
PB - Public Library of Science
SN - null
TODO - 10.1371/journal.pone.0118206
TODO - null
TODO - Background
Few epidemiological studies have examined the association between
dietary trans fatty acids and weight gain, and the evidence remains
inconsistent. The main objective of the study was to investigate the
prospective association between biomarker of industrial trans fatty
acids and change in weight within the large study European Prospective
Investigation into Cancer and Nutrition ( EPIC) cohort.
Methods
Baseline plasma fatty acid concentrations were determined in a
representative EPIC sample from the 23 participating EPIC centers. A
total of 1,945 individuals were followed for a median of 4.9 years to
monitor weight change. The association between elaidic acid level and
percent change of weight was investigated using a multinomial logistic
regression model, adjusted by length of follow- up, age, energy,
alcohol, smoking status, physical activity, and region.
Results
In women, doubling elaidic acid was associated with a decreased risk of
weight loss ( odds ratio ( OR) = 0.69, 95% confidence interval ( CI) =
0.55- 0.88, p = 0.002) and a trend was observed with an increased risk
of weight gain during the 5- year follow- up ( OR = 1.23, 95% CI =
0.97- 1.56, p = 0.082) ( p- trend<. 0001). In men, a trend was observed
for doubling elaidic acid level and risk of weight loss ( OR = 0.82,
95% CI = 0.66- 1.01, p = 0.062) while no significant association was
found with risk of weight gain during the 5- year follow- up ( OR =
1.08, 95% CI = 0.88- 1.33, p = 0.454). No association was found for
saturated and cismonounsaturated fatty acids.
Conclusions
These data suggest that a high intake of industrial trans fatty acids
may decrease the risk of weight loss, particularly in women. Prevention
of obesity should consider limiting the consumption of highly processed
foods, the main source of industrially- produced trans fatty acids.
ER -