TY - JOUR
TI - Hypoglycaemia requiring medical assistance in patients with diabetes: A
prospective multicentre survey in tertiary hospitals
AU - Liatis, S.
AU - Mylona, M.
AU - Kalopita, S.
AU - Papazafiropoulou, A. and
AU - Karamagkiolis, S.
AU - Melidonis, A.
AU - Xilomenos, A.
AU - Ioannidis, I.
AU - and Kaltsas, G.
AU - Lanaras, L.
AU - Papas, S.
AU - Basagiannis, C. and
AU - Kokkinos, A.
JO - Diabetes & Metabolism
PY - 2015
VL - 41
TODO - 2
SP - 126-131
PB - Masson Editeur
SN - 1262-3636
TODO - 10.1016/j.diabet.2014.10.006
TODO - Hypoglycaemia; Type 1 diabetes; Type 2 diabetes
TODO - Aim. - Hypoglycaemia is considered a factor contributing to morbidity
and mortality in patients with diabetes. The aim of the present study
was to examine the frequency, clinical characteristics, predisposing
factors and outcomes of iatrogenic hypoglycaemia requiring medical
assistance.
Methods. - Eight hospitals participated in this prospective survey of
documented iatrogenic hypoglycaemia at their emergency departments.
Cases with type 2 diabetes (T2D) were compared with a control group,
consisting of patients visiting the outpatients’ diabetes clinics of the
same hospitals during the same time period.
Results. - Median survey duration was 16.5 months, and 295 episodes of
iatrogenic hypoglycaemia were recorded. Frequency varied across centres
from 0.25 to 0.78 cases per 100 presenting patients. Most cases (90.8%)
were observed in patients with T2D (mean age: 76.7 +/- 10.1 years),
while 8.1% of events were recorded in patients with type 1 diabetes
(mean age: 42.7 +/- 18.3 years). Total in-hospital mortality was 3.4%,
and all involved patients with T2D. In T2D patients, advanced age (OR:
1.3 [1.20-1.45] for 5-year increase), use of sulphonylureas (OR: 4.0
[2.5-6.36]), use of insulin (OR: 2.35 [1.42-3.95]), lower estimated
GFR (OR: 1.15 [1.07-1.23] at 10 mL/min) and number of comorbidities
(OR: 1.74 [1.34-2.27]) were each independently associated with
hypoglycaemia requiring medical assistance.
Conclusion. - Hypoglycaemia requiring medical assistance in patients
with diabetes is a moderately common condition seen in emergency
departments and has a mortality rate of 3.4%. The majority of cases
involve elderly individuals with T2D who are suffering from serious
comorbidities and treated with insulin and/or sulphonylureas. (c) 2014
Elsevier Masson SAS. All rights reserved.
ER -