TY - JOUR
TI - A Prospective Study of the Immune System Activation Biomarker Neopterin
and Colorectal Cancer Risk
AU - Aleksandrova, Krasimira
AU - Chuang, Shu-Chun
AU - Boeing, Heiner
AU - Zuo,
AU - Hui
AU - Tell, Grethe S.
AU - Pischon, Tobias
AU - Jenab, Mazda and
AU - Bueno-de-Mesquita, Bas
AU - Vollset, Stein Emil
AU - Midttun, Oivind and
AU - Ueland, Per Magne
AU - Fedirko, Veronika
AU - Johansson, Mattias and
AU - Weiderpass, Elisabete
AU - Severi, Gianluca
AU - Racine, Antoine and
AU - Boutron-Ruault, Marie-Christine
AU - Kaaks, Rudolf
AU - Kuehn, Tilman and
AU - Tjonneland, Anne
AU - Overvad, Kim
AU - Ramon Quiros, J.
AU - Jakszyn,
AU - Paula
AU - Sanchez, Maria-Jose
AU - Dorronsoro, Miren
AU - Chirlaque,
AU - Maria-Dolores
AU - Ardanaz, Eva
AU - Khaw, Kay-Tee
AU - Wareham, Nicholas
AU - J.
AU - Travis, Ruth C.
AU - Trichopoulou, Antonia
AU - Lagiou, Pagona and
AU - Trichopoulos, Dimitrios
AU - Palli, Domenico
AU - Sieri, Sabina and
AU - Tumino, Rosario
AU - Panico, Salvatore
AU - May, Anne M.
AU - Palmqvist,
AU - Richard
AU - Ljuslinder, Ingrid
AU - Kong, So Yeon J.
AU - Freisling, Heinz
AU - and Gunter, Marc J.
AU - Lu, Yunxia
AU - Cross, Amanda J.
AU - Riboli, Elio
AU - and Vineis, Paolo
JO - JNCI Journal of the National Cancer Institute
PY - 2015
VL - 107
TODO - 4
SP - null
PB - OXFORD UNIV PRESS INC
SN - 0027-8874, 1460-2105
TODO - 10.1093/jnci/djv010
TODO - null
TODO - Background: Neopterin may be relevant for colorectal cancer (CRC)
development, as a biomarker of cellular immune activity exerting
pleiotropic effects on cellular ageing, oxidative stress, and
inflammation. So far, the association between prediagnostic neopterin
and colon and rectal cancer risk has not been evaluated in human
populations.
Methods: A nested case-control study was conducted within the European
Prospective Investigation into Cancer and Nutrition cohort using data on
plasma concentrations of total neopterin (T-N, sum of neopterin and
7,8-dihydroneopterin) in 830 incident CRC case patients (561 colon and
269 rectal) matched within risk sets to 830 control participants. A
subsequent replication study used data from the Hordaland Health Study,
where 173 CRC case patients have been diagnosed among 6594 healthy
participants over 12 years of follow-up.
Results: After multivariable adjustment for a priori chosen CRC risk
factors, a “U-shaped” association of T-N with CRC was revealed.
Compared with the second quintile of the T-N distribution, the relative
risks for the first, third, fourth, and fifth quintiles were 2.37 (95%
CI = 1.66 to 3.39), 1.24 (95% CI = 0.87 to 1.77), 1.55 (95% CI = 1.08
to 2.22), and 2.31 (95% CI = 1.63 to 3.27), respectively. Replication
of these associations within the Hordaland Health Study yielded similar
results. No differences have been observed when the associations were
explored by colon and rectal cancer site (two-sided P-difference = .87)
and after excluding case patients diagnosed within the first four
follow-up years.
Conclusions: These novel findings provide evidence of the role of both
suppressed and activated cell-mediated immunity as reflected by
prediagnostic T-N concentrations in the development of CRC.
ER -