TY - JOUR
TI - Association of clinicopathological characteristics with secondary
neoplastic lymphoproliferative disorders in patients with lymphomatoid
papulosis
AU - Nikolaou, Vassiliki
AU - Papadavid, Evangelia
AU - Ekonomidi, Afroditi and
AU - Dalamaga, Maria
AU - Marinos, Leonidas
AU - Stratigos, Alexandros and
AU - Papadaki, Theodora
AU - Antoniou, Christina
JO - Leukemia & Lymphoma
PY - 2015
VL - 56
TODO - 5
SP - 1303-1307
PB - TAYLOR & FRANCIS LTD LONDON
SN - 1042-8194, 1029-2403
TODO - 10.3109/10428194.2014.958821
TODO - Lymphoma and Hodgkin disease; prognostication; chemotherapeutic
approaches
TODO - Lymphomatoid papulosis (LyP) refers to an indolent cutaneous lymphoma.
The association of prognostic clinicopathological risk factors with a
second hematologic malignancy has not yet been determined. We
investigated the prognostic effect of clinicopathological
characteristics on the occurrence of a second lymphoma, as well as the
first-line treatment, in 24 patients diagnosed with LyP using logistic
regression models. We showed that lymphoma occurrence was associated
with a lower mean age at onset of LyP symptoms, histological types B and
C, head-located LyP lesions and a higher frequency of LyP recurrences.
In multivariate analyses, histologic type A was associated with a lower
risk of second lymphoma (odds ratio [OR] = 0.12, 95% confidence
interval [CI] 0.014-0.98; p = 0.045) adjusting for age of LyP first
symptomatology, and an important increased lymphoma-free survival rate
(long-rank test; p = 0.06). Clinicopathological characteristics are
important in defining the clearance or persistence of LyP lesions and
may predict the occurrence of a second lymphoma.
ER -