TY - JOUR
TI - Influence of light exposure during early life on the age of onset of
bipolar disorder
AU - Bauer, Michael
AU - Glenn, Tasha
AU - Alda, Martin
AU - Andreassen, Ole A.
AU - and Angelopoulos, Elias
AU - Ardau, Raffaella
AU - Baethge, Christopher
AU - and Bauer, Rita
AU - Baune, Bernhard T.
AU - Bellivier, Frank and
AU - Belmaker, Robert H.
AU - Berk, Michael
AU - Bjella, Thomas D.
AU - Bossini,
AU - Letizia
AU - Bersudsky, Yuly
AU - Cheung, Eric Yat Wo
AU - Conell, Joern
AU - and Del Zompo, Maria
AU - Dodd, Seetal
AU - Etain, Bruno
AU - Fagiolini,
AU - Andrea
AU - Frye, Mark A.
AU - Fountoulakis, Kostas N. and
AU - Garneau-Fournier, Jade
AU - Gonzalez-Pinto, Ana
AU - Gottlieb, John F. and
AU - Harima, Hirohiko
AU - Hassel, Stefanie
AU - Henry, Chantal
AU - Iacovides,
AU - Apostolos
AU - Isometsa, Erkki T.
AU - Kapczinski, Flavio
AU - Kliwicki,
AU - Sebastian
AU - Koenig, Barbara
AU - Krogh, Rikke
AU - Kunz, Mauricio and
AU - Lafer, Beny
AU - Larsen, Erik R.
AU - Lewitzka, Ute
AU - Lopez-Jaramillo,
AU - Carlos
AU - MacQueen, Glenda
AU - Manchia, Mirko
AU - Marsh, Wendy and
AU - Martinez-Cengotitabengo, Monica
AU - Melle, Ingrid
AU - Monteith, Scott
AU - and Morken, Gunnar
AU - Munoz, Rodrigo
AU - Nery, Fabiano G. and
AU - O'Donovan, Claire
AU - Osher, Yamima
AU - Pfennig, Andrea
AU - Quiroz,
AU - Danilo
AU - Ramesar, Raj
AU - Rasgon, Natalie
AU - Reif, Andreas and
AU - Ritter, Philipp
AU - Rybakowski, Janusz K.
AU - Sagduyu, Kemal and
AU - Miranda-Scippa, Angela
AU - Severus, Emanuel
AU - Simhandl, Christian and
AU - Stein, Dan J.
AU - Strejilevich, Sergio
AU - Sulaiman, Ahmad Hatim and
AU - Suominen, Kirsi
AU - Tagata, Hiromi
AU - Tatebayashi, Yoshitaka and
AU - Torrent, Carla
AU - Vieta, Eduard
AU - Viswanath, Biju
AU - Wanchoo, Mihir
AU - J.
AU - Zetin, Mark
AU - Whybrow, Peter C.
JO - Journal of Psychiatric Research
PY - 2015
VL - 64
TODO - null
SP - 1-8
PB - PERGAMON-ELSEVIER SCIENCE LTD
SN - 0022-3956
TODO - 10.1016/j.jpsychires.2015.03.013
TODO - Bipolar disorder; Age of onset; Sunlight; Insolation; Hours of daylight
TODO - Background: Environmental conditions early in life may imprint the
circadian system and influence response to environmental signals later
in life. We previously determined that a large springtime increase in
solar insolation at the onset location was associated with a younger age
of onset of bipolar disorder, especially with a family history of mood
disorders. This study investigated whether the hours of daylight at the
birth location affected this association.
Methods: Data collected previously at 36 collection sites from 23
countries were available for 3896 patients with bipolar I disorder, born
between latitudes of 1.4 N and 70.7 N, and 1.2 S and 413 S. Hours of
daylight variables for the birth location were added to a base model to
assess. the relation between the age of onset and solar insolation.
Results: More hours of daylight at the birth location during early life
was associated with an older age of onset, suggesting reduced
vulnerability to the future circadian challenge of the springtime
increase in solar insolation at the onset location. Addition of the
minimum of the average monthly hours of daylight during the first 3
months of life improved the base model, with a significant positive
relationship to age of onset. Coefficients for all other variables
remained stable, significant and consistent with the base model.
Conclusions: Light exposure during early life may have important
consequences for those who are susceptible to bipolar disorder,
especially at latitudes with little natural light in winter. This study
indirectly supports the concept that early life exposure to light may
affect the long term adaptability to respond to a circadian challenge
later in life. (C) 2015 Elsevier Ltd. All rights reserved.
ER -