TY - JOUR
TI - Genome-wide association of polycystic ovary syndrome implicates
alterations in gonadotropin secretion in European ancestry populations
AU - Hayes, M. Geoffrey
AU - Urbanek, Margrit
AU - Ehrmann, David A. and
AU - Armstrong, Loren L.
AU - Lee, Ji Young
AU - Sisk, Ryan
AU - Karaderi, Tugce
AU - and Barber, Thomas M.
AU - McCarthy, Mark I.
AU - Franks, Stephen and
AU - Lindgren, Cecilia M.
AU - Welt, Corrine K.
AU - Diamanti-Kandarakis,
AU - Evanthia
AU - Panidis, Dimitrios
AU - Goodarzi, Mark O.
AU - Azziz, Ricardo
AU - and Zhang, Yi
AU - James, Roland G.
AU - Olivier, Michael
AU - Kissebah,
AU - Ahmed H.
AU - Stener-Victorin, Elisabet
AU - Legro, Richard S.
AU - Dunaif,
AU - Andrea
AU - Reprod Med Network
JO - Nature Communications
PY - 2015
VL - 6
TODO - null
SP - null
PB - Nature Publishing Group
SN - 2041-1723
TODO - 10.1038/ncomms8502
TODO - null
TODO - Polycystic ovary syndrome (PCOS) is a common, highly heritable complex
disorder of unknown aetiology characterized by hyperandrogenism, chronic
anovulation and defects in glucose homeostasis. Increased luteinizing
hormone relative to follicle-stimulating hormone secretion, insulin
resistance and developmental exposure to androgens are hypothesized to
play a causal role in PCOS. Here we map common genetic susceptibility
loci in European ancestry women for the National Institutes of Health
PCOS phenotype, which confers the highest risk for metabolic
morbidities, as well as reproductive hormone levels. Three loci reach
genome-wide significance in the case-control meta-analysis, two novel
loci mapping to chr 8p32.1 and chr 11p14.1, and a chr 9q22.32 locus
previously found in Chinese PCOS. The same chr 11p14.1 SNP, rs11031006,
in the region of the follicle-stimulating hormone B polypeptide (FSHB)
gene strongly associates with PCOS diagnosis and luteinizing hormone
levels. These findings implicate neuroendocrine changes in disease
pathogenesis.
ER -