TY - JOUR
TI - The role of microRNAs in the pathogenesis of endometrial cancer: a
systematic review
AU - Sianou, Argiri
AU - Galyfos, George
AU - Moragianni, Dimitra and
AU - Andromidas, Panagiotis
AU - Kaparos, Georgios
AU - Baka, Stavroula and
AU - Kouskouni, Evangelia
JO - Archives of Gynecology and Obstetrics
PY - 2015
VL - 292
TODO - 2
SP - 271-282
PB - Springer Berlin Heidelberg
SN - 0932-0067, 1432-0711
TODO - 10.1007/s00404-015-3660-y
TODO - Micrornas; Endometrial cancer; Carcinogenesis; Apoptosis; Metastasis;
Epithelial to mesenchymal transition
TODO - Epigenetics seem to play a primary role in the current research on the
pathogenesis of different types of endometrial cancer. Data so far
indicate that microRNAs regulate different pathways that could lead to
carcinogenesis when not functioning properly. The aim of this review is
to summarize current knowledge on microRNAs that have been associated
with endometrial cancer development.
From July 2014 to August 2014, we conducted a comprehensive research
utilizing major online search engines (Pubmed, Crossref, Google
Scholar). The main keywords used in our search were endometrial
cancer/carcinoma; microRNA; epigenetics; novel biomarkers; pathogenesis.
Overall, we identified 155 studies, although only 77 were eligible for
this review. Different miRNAs were identified to contribute either
promoting the carcinogenesis in the endometrium or inhibiting different
steps of endometrial cancer development. Tumour growth, cell
proliferation, apoptosis and invasion metastasis have been identified as
the main processes where miRNAs seem to be implicated.
microRNAs are effective regulators of gene expression that has a
significant role in the pathogenesis of endometrial cancer. Research
concerning possible therapeutic implications has been promising,
although there is still a significant distance to be covered between
research observations and clinical results. Extensive preclinical and
translational research is still required to improve the efficacy and
minimize unwanted effects of miRNAs-based therapy.
ER -